{
  "dataset": "Purely Peptides Research Library",
  "file": "classes",
  "description": "Published compound classes.",
  "version": "2026-10-21",
  "license": "CC-BY-4.0",
  "licenseUrl": "https://creativecommons.org/licenses/by/4.0/",
  "attribution": "Purely Peptides Research Library, https://purelypeptides.org/research/, licensed CC BY 4.0",
  "notice": "Research reference data about peptide identity, structure and the published literature. It is not product information, makes no claim about any product, and is not medical advice.",
  "count": 22,
  "records": [
    {
      "id": "glp-1-receptor-peptide-analogs",
      "url": "https://purelypeptides.org/research/classes/glp-1-receptor-peptide-analogs/",
      "name": "GLP-1 receptor peptide analogs",
      "description": "Designed peptide analogs whose declared molecular relationship is agonism at the glucagon-like peptide-1 receptor.",
      "relatedClassIds": [
        "multi-receptor-incretin-analogs",
        "nonpeptide-receptor-agonists"
      ],
      "referenceIds": [
        "pmid-26308095",
        "pmid-34260945",
        "pmid-31031702"
      ]
    },
    {
      "id": "multi-receptor-incretin-analogs",
      "url": "https://purelypeptides.org/research/classes/multi-receptor-incretin-analogs/",
      "name": "Multi-receptor incretin analogs",
      "description": "Single peptide molecules characterized against more than one receptor in the incretin and glucagon receptor families.",
      "relatedClassIds": [
        "glp-1-receptor-peptide-analogs",
        "incretin-and-glucagon-receptor-ligands"
      ],
      "referenceIds": [
        "pmid-35985340",
        "pmid-37366315",
        "pmid-37385280"
      ]
    },
    {
      "id": "kisspeptins",
      "url": "https://purelypeptides.org/research/classes/kisspeptins/",
      "name": "Kisspeptins",
      "description": "Peptides derived from the KISS1 precursor that share a C-terminal RF-amide motif and bind the kisspeptin receptor.",
      "relatedClassIds": [
        "neuropeptides-and-derived-fragments"
      ],
      "referenceIds": [
        "pmid-11385580",
        "pmid-11457843",
        "pmid-11387329"
      ]
    },
    {
      "id": "regenerative-peptides",
      "url": "https://purelypeptides.org/research/classes/regenerative-peptides/",
      "name": "Regenerative peptides",
      "description": "Synthetic peptides studied in connective-tissue and epithelial repair models, grouped by shared experimental context rather than by a common receptor.",
      "relatedClassIds": [
        "copper-binding-peptides"
      ]
    },
    {
      "id": "copper-binding-peptides",
      "url": "https://purelypeptides.org/research/classes/copper-binding-peptides/",
      "name": "Copper-binding peptides",
      "description": "Peptides whose defining chemical feature is high-affinity coordination of Cu(II), forming discrete metal-peptide complexes with molecular identities distinct from the free peptide.",
      "relatedClassIds": [
        "regenerative-peptides"
      ],
      "referenceIds": [
        "pmid-6291585",
        "pmid-7340824",
        "pmid-37624577",
        "pmid-2244543"
      ]
    },
    {
      "id": "ghrh-analogs",
      "url": "https://purelypeptides.org/research/classes/ghrh-analogs/",
      "name": "GHRH analogs",
      "description": "Synthetic analogs of growth hormone-releasing factor, typically modified fragments of the 44-residue human sequence, acting at the GHRH receptor.",
      "relatedClassIds": [
        "growth-hormone-secretagogues"
      ],
      "referenceIds": [
        "pmid-19243281"
      ]
    },
    {
      "id": "growth-hormone-secretagogues",
      "url": "https://purelypeptides.org/research/classes/growth-hormone-secretagogues/",
      "name": "Growth hormone secretagogues",
      "description": "Endogenous peptide ligands, synthetic peptides and nonpeptide mimetics acting at the growth hormone secretagogue receptor (the ghrelin receptor), a distinct receptor from the GHRH receptor targeted by GHRH analogs.",
      "relatedClassIds": [
        "ghrh-analogs"
      ],
      "referenceIds": [
        "pmid-9849822"
      ]
    },
    {
      "id": "mitochondrial-derived-peptides",
      "url": "https://purelypeptides.org/research/classes/mitochondrial-derived-peptides/",
      "name": "Mitochondrial-derived peptides",
      "description": "Peptides encoded by short open reading frames within the mitochondrial genome rather than the nuclear genome.",
      "relatedClassIds": [],
      "referenceIds": [
        "pmid-25738459"
      ]
    },
    {
      "id": "regulatory-peptide-fragment-analogs",
      "url": "https://purelypeptides.org/research/classes/regulatory-peptide-fragment-analogs/",
      "name": "Regulatory peptide fragment analogs",
      "description": "Short synthetic peptides constructed from a fragment of a larger endogenous regulatory peptide, commonly extended with a stabilizing C-terminal sequence.",
      "relatedClassIds": [
        "melanocortin-fragment-peptides",
        "matrikine-derived-peptides",
        "neuropeptides-and-derived-fragments",
        "neurotrophic-peptide-mimetics"
      ]
    },
    {
      "id": "thymosin-related-peptides",
      "url": "https://purelypeptides.org/research/classes/thymosin-related-peptides/",
      "name": "Thymosin-related peptides",
      "description": "Peptides originally isolated from thymic tissue fractions, subsequently characterized as having functions unrelated to thymic hormone activity.",
      "relatedClassIds": [],
      "referenceIds": [
        "pmid-17468232"
      ]
    },
    {
      "id": "melanocortin-fragment-peptides",
      "url": "https://purelypeptides.org/research/classes/melanocortin-fragment-peptides/",
      "name": "Melanocortin fragment peptides",
      "description": "Short peptides corresponding to fragments of melanocortin hormones, retaining part of the parent sequence while lacking the residues required for melanocortin receptor binding.",
      "relatedClassIds": [
        "regulatory-peptide-fragment-analogs",
        "cyclic-melanocortin-analogs",
        "linear-melanocortin-analogs",
        "melanocortin-receptor-ligands"
      ],
      "referenceIds": [
        "pmid-11268347"
      ]
    },
    {
      "id": "nonpeptide-receptor-agonists",
      "url": "https://purelypeptides.org/research/classes/nonpeptide-receptor-agonists/",
      "name": "Nonpeptide receptor agonists",
      "description": "Small molecules characterized as agonists at receptors whose endogenous ligands are peptides, included here for comparison with the peptide agonists at the same receptor.",
      "relatedClassIds": [
        "glp-1-receptor-peptide-analogs"
      ],
      "referenceIds": [
        "pmid-39693407",
        "pmid-33177239"
      ]
    },
    {
      "id": "matrikine-derived-peptides",
      "url": "https://purelypeptides.org/research/classes/matrikine-derived-peptides/",
      "name": "Matrikine-derived peptides",
      "description": "Peptides corresponding to fragments of extracellular matrix proteins, typically studied for their reported effects on matrix synthesis in fibroblast culture.",
      "relatedClassIds": [
        "regulatory-peptide-fragment-analogs"
      ],
      "referenceIds": [
        "pmid-21535443"
      ]
    },
    {
      "id": "cyclic-melanocortin-analogs",
      "url": "https://purelypeptides.org/research/classes/cyclic-melanocortin-analogs/",
      "name": "Cyclic melanocortin analogs",
      "description": "Synthetic melanocortin receptor ligands closed into a macrocycle by a side-chain to side-chain bridge, in contrast to the linear fragment and full-length melanocortin peptides.",
      "relatedClassIds": [
        "melanocortin-fragment-peptides",
        "linear-melanocortin-analogs",
        "melanocortin-receptor-ligands"
      ],
      "referenceIds": [
        "pmid-35188390",
        "pmid-42340853"
      ]
    },
    {
      "id": "amylin-and-calcitonin-receptor-agonists",
      "url": "https://purelypeptides.org/research/classes/amylin-and-calcitonin-receptor-agonists/",
      "name": "Amylin and calcitonin receptor agonists",
      "description": "Peptides that engage the calcitonin receptor and the amylin receptor complexes it forms with receptor activity-modifying proteins. Described as amylin analogs, they are not amylin-receptor-exclusive.",
      "relatedClassIds": [],
      "referenceIds": [
        "pmid-40204768"
      ]
    },
    {
      "id": "linear-melanocortin-analogs",
      "url": "https://purelypeptides.org/research/classes/linear-melanocortin-analogs/",
      "name": "Linear melanocortin analogs",
      "description": "Full-length melanocortin peptide analogs that retain a linear backbone, distinguished from the cyclic lactam analogs and from the short melanocortin fragments.",
      "relatedClassIds": [
        "cyclic-melanocortin-analogs",
        "melanocortin-fragment-peptides",
        "melanocortin-receptor-ligands"
      ],
      "referenceIds": [
        "pmid-6777774"
      ]
    },
    {
      "id": "neurotrophic-peptide-mimetics",
      "url": "https://purelypeptides.org/research/classes/neurotrophic-peptide-mimetics/",
      "name": "Neurotrophic peptide mimetics",
      "description": "Small synthetic peptides designed to mimic regions of neurotrophic factors, typically characterised through downstream pathway readouts rather than a demonstrated direct receptor target.",
      "relatedClassIds": [
        "regulatory-peptide-fragment-analogs"
      ],
      "referenceIds": [
        "pmid-20600002"
      ]
    },
    {
      "id": "melanocortin-receptor-ligands",
      "url": "https://purelypeptides.org/research/classes/melanocortin-receptor-ligands/",
      "name": "Melanocortin receptor ligands",
      "description": "An umbrella for everything that acts at the melanocortin receptors regardless of chemistry — the native hormones, their fragments, cyclic analogs and nonpeptide small molecules. It exists so the native hormone is not filed as an analog of itself and a nonpeptide is not filed in a peptide class.",
      "relatedClassIds": [
        "cyclic-melanocortin-analogs",
        "linear-melanocortin-analogs",
        "melanocortin-fragment-peptides"
      ],
      "referenceIds": [
        "pmid-34433901",
        "pmid-7658432"
      ]
    },
    {
      "id": "incretin-and-glucagon-receptor-ligands",
      "url": "https://purelypeptides.org/research/classes/incretin-and-glucagon-receptor-ligands/",
      "name": "Incretin and glucagon receptor ligands",
      "description": "Endogenous hormones acting at the GLP-1, GIP and glucagon receptors, held together without any claim of common chemical ancestry. It exists so native hormones are not filed in a class of analogs of themselves.",
      "relatedClassIds": [
        "multi-receptor-incretin-analogs"
      ],
      "referenceIds": [
        "pmid-8100523"
      ]
    },
    {
      "id": "neuropeptides-and-derived-fragments",
      "url": "https://purelypeptides.org/research/classes/neuropeptides-and-derived-fragments/",
      "name": "Neuropeptides and derived fragments",
      "description": "A navigation class for endogenous neuropeptides and synthetic fragments derived from them. Membership does not imply a shared precursor, receptor or mechanism.",
      "relatedClassIds": [
        "kisspeptins",
        "regulatory-peptide-fragment-analogs"
      ],
      "referenceIds": [
        "pmid-24517231"
      ]
    },
    {
      "id": "aromatic-cationic-tetrapeptides",
      "url": "https://purelypeptides.org/research/classes/aromatic-cationic-tetrapeptides/",
      "name": "Aromatic cationic tetrapeptides",
      "description": "Synthetic linear tetrapeptide amides with alternating aromatic residues and basic amino-acid residues, in either aromatic–basic–aromatic–basic or basic–aromatic–basic–aromatic order.",
      "relatedClassIds": [],
      "referenceIds": [
        "pmid-35913044"
      ]
    },
    {
      "id": "gnrh-peptide-analogs",
      "url": "https://purelypeptides.org/research/classes/gnrh-peptide-analogs/",
      "name": "GnRH peptide analogs",
      "description": "Synthetic peptide analogs of the hypothalamic GnRH decapeptide with direct experimental evidence of binding the GnRH receptor. Each member carries its own substitutions, so membership does not imply identical chemistry.",
      "relatedClassIds": [],
      "referenceIds": [
        "pmid-26398856"
      ]
    }
  ]
}