DSIP (Delta Sleep-Inducing Peptide)
10mg
Delta sleep-inducing peptide (DSIP) is a naturally occurring neuropeptide first isolated from the cerebral venous blood of rabbits during electrically induced sleep in 1977 by Schoenenberger and Monnier. This nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) crosses the blood-brain barrier and has been investigated for its role in modulating slow-wave sleep architecture, stress response, and neuroendocrine regulation. DSIP has also shown research interest in pain modulation and opioid withdrawal contexts.
Pricing
Mechanism of Action
The precise receptor target of DSIP remains under investigation. Research suggests DSIP modulates GABAergic and glutamatergic neurotransmission, interacts with the hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol and ACTH levels, and may influence circadian rhythm regulation through effects on melatonin and serotonin pathways. It has also been shown to modulate delta-wave EEG activity, the characteristic oscillation pattern of deep (stage N3) sleep.
Properties
Molecular Formula
C₃₅H₄₈N₁₀O₁₅
Molecular Weight
848.81 Da
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Half-Life
~7-8 minutes (rapid peripheral degradation)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(3)Characterization of a delta-electroencephalogram sleep-inducing peptide
Schoenenberger GA, Monnier M.
Delta sleep-inducing peptide: Structural analogs and their biological activity
Prudchenko IA, Starostina MV, Bhargava HN, et al.
Delta sleep-inducing peptide (DSIP): A still unresolved riddle
Kovalzon VM, Strekalova TV.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.