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Catalog/DSIP (Delta Sleep-Inducing Peptide)
DSIP (Delta Sleep-Inducing Peptide)
#1005
Lyophilized Peptide

DSIP (Delta Sleep-Inducing Peptide) 10mg

Delta sleep-inducing peptide (DSIP) is a nonapeptide first isolated from the cerebral venous blood of rabbits during electrically induced sleep in 1977 by Schoenenberger and Monnier. Its sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. Its name reflects early rabbit EEG observations; the cited 2006 review describes its natural occurrence and biological activity as unresolved. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.

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Single (10mg)$30.00

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  • Certificates published per tested lot — see current coverage

Mechanism of Action

The precise receptor target of DSIP remains under investigation. Schoenenberger and Monnier reported enhanced delta and spindle EEG patterns after intraventricular infusion of synthetic DSIP in rabbits. Kovalzon and Strekalova's 2006 review describes the sleep-factor hypothesis as poorly documented and reports that DSIP itself did not promote slow-wave sleep in their cited rabbit and rat experiments.

Properties

CAS Number

62568-57-4

Molecular Formula

C₃₅H₄₈N₁₀O₁₅

Molecular Weight

848.81 Da

Sequence

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Half-Life

~2-4 min (rat/dog plasma, intravenous)

Storage

Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.

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Quality & Testing

  • No third-party certificate has been published for this compound yet.
  • USA-based; dispatched from Phoenix, Arizona.
  • Supplied strictly for in-vitro laboratory research — not for human use.

Certificates are published for each lot we have tested — see the 14 published so far.

Research Applications

1Sleep architecture and slow-wave sleep modulation
2HPA axis and stress response regulation
3EEG delta-wave activity quantification
4Neuropeptide blood-brain barrier transport studies
5Opioid-withdrawal neuroadaptation models

References & Citations

(3)
1

Development of an enzyme immunoassay for delta sleep-inducing peptide (DSIP) and its use in the determination of the metabolic clearance rate of DSIP administered to dogs.

Kato N, Honda Y, Ebihara S, Naruse H, Takahashi Y

Neuroendocrinology (1984)PMID: 6379493 DOI
2

Characterization of a delta-electroencephalogram (-sleep)-inducing peptide

Schoenenberger GA, Monnier M.

Proc Natl Acad Sci USA (1977)PMID: 265572 DOI
3

Delta sleep-inducing peptide (DSIP): a still unresolved riddle

Kovalzon VM, Strekalova TV.

J Neurochem (2006)PMID: 16539679 DOI

Research Use Only

This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.

Research reference

A published identity, mechanism, and bibliography record corresponds to this catalog entry.

Research reference: DSIP