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Catalog/Semaglutide
Semaglutide
#1001
Lyophilized Peptide

Semaglutide 10mg

Semaglutide is an acylated analog of human GLP-1 with Aib8 and Arg34 substitutions and derivatization at Lys26. Its receptor affinity and albumin binding were characterized in the discovery study by Lau et al. (2015). The reported mini-pig plasma pharmacokinetics do not establish an in-vitro half-life. This listing contains 10mg of lyophilized material. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.

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  • Third-party tested — lot SEM-20260811-01 at 99.78% purity

Batch Tracking

Batch #

SEM-20260811-01

Tested

2026-08-23

Purity

99.78%

Method

RP-HPLC (214 nm)

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Mechanism of Action

Semaglutide is a GLP-1 receptor agonist. Lau et al. (2015) characterized receptor affinity and albumin binding while optimizing acylated GLP-1 analogs. Semaglutide contains Aib8 and Arg34 substitutions and a Lys26-linked substituent; the study reported increased albumin affinity relative to liraglutide.

Properties

CAS Number

910463-68-2

Molecular Formula

C₁₈₇H₂₉₁N₄₅O₅₉

Molecular Weight

4113.64 Da

Sequence

His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18 diacid-γGlu-OEG-OEG)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly

Half-Life

In-vitro half-life not established by the cited discovery study

Storage

Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 30 days.

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Quality & Testing

  • Independently tested by Bioviridian Inc. — identity by LC-MS/MS, purity by RP-HPLC (214 nm).
  • Measured at 99.78% purity on lot SEM-20260811-01.
  • USA-based; dispatched from Phoenix, Arizona.
  • Supplied strictly for in-vitro laboratory research — not for human use.
Lot SEM-20260811-01 · 99.78% purity · certificate COA7919

Research Applications

1GLP-1 receptor affinity characterization
2Albumin-binding comparisons
3Acylated GLP-1 analog structure-activity research

References & Citations

(1)
1

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

Lau J, Bloch P, Schäffer L, et al.

J Med Chem (2015)PMID: 26308095 DOI

Research Use Only

This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.

Research reference

A published identity, mechanism, and bibliography record corresponds to this catalog entry.

Research reference: Semaglutide