Semaglutide
10mg
Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist originally developed for the treatment of type 2 diabetes and subsequently approved for chronic weight management. It is a 31-amino acid peptide analog of human GLP-1(7-37) with a C-18 fatty diacid chain attached via a linker to Lys26, conferring high albumin binding affinity and resistance to DPP-4 degradation. This structural modification extends its pharmacokinetic half-life to approximately 7 days, enabling once-weekly administration in clinical settings.
Pricing
Mechanism of Action
Semaglutide activates the GLP-1 receptor, a class B G-protein coupled receptor expressed in pancreatic beta cells, the gastrointestinal tract, and the central nervous system. Receptor activation stimulates glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and modulates hypothalamic appetite circuits to reduce food intake. In research models, semaglutide has demonstrated effects on hepatic lipid metabolism, cardiovascular inflammation markers, and neuroinflammatory pathways.
Properties
Molecular Formula
C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight
4113.58 Da
Sequence
His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18 diacid-γGlu-OEG-OEG)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
Half-Life
~7 days (albumin-bound)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 30 days.
Research Applications
References & Citations
(4)Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
Wilding JPH, Batterham RL, Calanna S, et al.
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6)
Marso SP, Bain SC, Consoli A, et al.
A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis
Newsome PN, Buchholtz K, Cusi K, et al.
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT)
Kaplan A, Bhatt DL, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.