SS-31 (Elamipretide)
10mg
SS-31 (elamipretide, D-Arg-2',6'-Dmt-Lys-Phe-NH₂) is a cell-permeable aromatic-cationic tetrapeptide that selectively targets the inner mitochondrial membrane. Developed by Dr. Hazel Szeto and Dr. Peter Schiller, SS-31 concentrates at the inner mitochondrial membrane by binding cardiolipin, a phospholipid unique to this compartment. It has demonstrated potent cytoprotective effects in models of ischemia-reperfusion injury, heart failure, neurodegeneration, and aging.
Pricing
Mechanism of Action
SS-31 binds cardiolipin on the inner mitochondrial membrane, stabilizing its interaction with cytochrome c and preserving electron transport chain (ETC) function. By preventing cardiolipin peroxidation and cytochrome c release, SS-31 maintains mitochondrial membrane potential, reduces reactive oxygen species (ROS) production, and inhibits apoptosis. It also promotes cristae remodeling via OPA1 stabilization, restoring mitochondrial architecture impaired by aging or disease. SS-31 does not require receptor binding — its activity is purely membrane-targeted.
Properties
Molecular Formula
C₃₂H₄₉N₇O₆
Molecular Weight
639.79 Da
Sequence
D-Arg-2',6'-Dmt-Lys-Phe-NH₂
Half-Life
~2-4 hours
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(3)First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
Szeto HH.
Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress
Dai DF, Hsieh EJ, Liu Y, et al.
Mitochondrial protein interaction landscape of SS-31
Chavez JD, Tang X, Campbell MD, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.