GHK-CU 100mg
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. Plasma levels decline from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60. Originally identified by Dr. Loren Pickart in 1973 as a factor in human plasma that promoted hepatocyte function, GHK-Cu has since been shown to influence the expression of over 4,000 human genes, broadly resetting gene expression patterns toward an altered phenotypic profile in gene array studies. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Third-party tested to a 99%+ purity standard
Mechanism of Action
GHK-Cu chelates copper(II) ions with high affinity, delivering bioavailable copper to tissues where it is required for enzymatic activity (lysyl oxidase, superoxide dismutase, cytochrome c oxidase). The peptide activates tissue-repair cascades including collagen I/III synthesis, glycosaminoglycan accumulation, and decorin expression. It suppresses inflammatory cytokines (TNF-α, IL-6, TGF-β1), upregulates DNA repair genes (GADD45A, XPC), modulates metalloproteinase activity (increasing MMP-2, reducing MMP-9), and promotes nerve outgrowth and angiogenesis.
Properties
Molecular Formula
C₁₄H₂₄CuN₆O₄
Molecular Weight
403.92 Da
Sequence
Gly-His-Lys:Cu²⁺
Half-Life
~1-2 hours
Storage
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C, use within 7 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- Independently tested by accredited third-party laboratories.
- Held to a 99%+ purity standard.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Batch test records are published to each product as they are completed.
Research Applications
References & Citations
(3)GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
Pickart L, Vasquez-Soltero JM, Margolina A.
GHK-Cu may prevent oxidative stress in skin by regulating copper and modifying expression of numerous antioxidant genes
Pickart L, Vasquez-Soltero JM, Margolina A.
The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice
Park JR, Lee H, Kim SI, Yang SR.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.