GHK-CU
100mg
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. Plasma levels decline from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60. Originally identified by Dr. Loren Pickart in 1973 as a factor in human plasma that promoted hepatocyte function, GHK-Cu has since been shown to influence the expression of over 4,000 human genes, broadly resetting gene expression patterns toward a healthier phenotypic profile in gene array studies.
Pricing
Mechanism of Action
GHK-Cu chelates copper(II) ions with high affinity, delivering bioavailable copper to tissues where it is required for enzymatic activity (lysyl oxidase, superoxide dismutase, cytochrome c oxidase). The peptide activates wound healing cascades including collagen I/III synthesis, glycosaminoglycan accumulation, and decorin expression. It suppresses inflammatory cytokines (TNF-α, IL-6, TGF-β1), upregulates DNA repair genes (GADD45A, XPC), modulates metalloproteinase activity (increasing MMP-2, reducing MMP-9), and promotes nerve outgrowth and angiogenesis.
Properties
Molecular Formula
C₁₄H₂₄CuN₆O₄
Molecular Weight
403.92 Da
Sequence
Gly-His-Lys:Cu²⁺
Half-Life
~1-2 hours
Storage
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C, use within 7 days.
Research Applications
References & Citations
(3)GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
Pickart L, Vasquez-Soltero JM, Margolina A.
GHK-Cu may prevent oxidative stress in skin by regulating copper and modifying expression of numerous antioxidant genes
Pickart L, Vasquez-Soltero JM, Margolina A.
The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice
Park JR, Lee H, Kim SI, Yang SR.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.