HCG (Gonadorelin)
10Kiu
Human chorionic gonadotropin (HCG) is a glycoprotein hormone consisting of an alpha subunit (common to LH, FSH, TSH) and a unique beta subunit that confers biological specificity. HCG mimics luteinizing hormone (LH) activity by binding the LH/CG receptor on Leydig cells and ovarian theca cells. It has a significantly longer half-life than LH due to its greater degree of glycosylation. Gonadorelin (GnRH analog) may also be included in this listing as a hypothalamic releasing factor that stimulates endogenous LH/FSH release from the pituitary.
Pricing
Mechanism of Action
HCG binds the LH/CG receptor (LHCGR), a Gs-coupled GPCR on testicular Leydig cells, activating cAMP/PKA signaling that stimulates steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme (CYP11A1), thereby driving de novo testosterone biosynthesis. In ovarian tissue, HCG triggers final oocyte maturation, ovulation, and corpus luteum formation. HCG also maintains intratesticular testosterone concentrations necessary for spermatogenesis, independently of pituitary LH.
Properties
Molecular Weight
~36,700 Da
Half-Life
~24-36 hours
Storage
Store lyophilized at 2-8°C. Reconstituted at 2-8°C, use within 30 days.
Research Applications
References & Citations
(2)Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression
Coviello AD, Matsumoto AM, Bremner WJ, et al.
Biological functions of hCG and hCG-related molecules
Cole LA.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.