KPV 10mg
KPV is a C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte stimulating hormone (α-MSH). Despite its minimal size, KPV retains the potent anti-inflammatory activity of the parent hormone while lacking its melanogenic and melanocortin receptor-dependent effects. KPV exerts anti-inflammatory action through a distinct, MC1R-independent mechanism, making it a unique tool for studying anti-inflammatory peptide signaling without melanocortin pathway engagement. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Third-party tested to a 99%+ purity standard
Mechanism of Action
KPV inhibits NF-κB activation by directly entering cells and interacting with the p65 subunit of the NF-κB transcription factor, preventing nuclear translocation. This suppresses transcription of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6), chemokines, and adhesion molecules. KPV also inhibits inflammasome activation and reduces IL-8 production in intestinal epithelial cells. Notably, this mechanism does not require melanocortin receptor binding, distinguishing KPV from full-length α-MSH and other melanocortin peptides.
Properties
Molecular Formula
C₁₆H₃₀N₄O₄
Molecular Weight
342.43 Da
Sequence
Lys-Pro-Val
Half-Life
~30-60 minutes
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- Independently tested by accredited third-party laboratories.
- Held to a 99%+ purity standard.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Batch test records are published to each product as they are completed.
Research Applications
References & Citations
(2)Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Kannengiesser K, Maaser C, Heidemann J, et al.
α-Melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory and protective effects in vitro and in vivo
Brzoska T, Luger TA, Maaser C, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.