KPV 10mg
KPV is a C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte stimulating hormone (α-MSH). Despite its minimal size, KPV retains the potent anti-inflammatory activity of the parent hormone while lacking its melanogenic effects. Kannengiesser et al. reported anti-inflammatory effects that were at least partially independent of MC1R signaling in mouse colitis models. This does not establish independence from every melanocortin receptor. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Plain, secure packaging
- Third-party tested — lot KPV-20260828-01 at 99.74% purity
Batch Tracking
Batch #
KPV-20260828-01
Tested
2026-09-08
Purity
99.74%
Method
RP-HPLC (214 nm)
Mechanism of Action
Dalmasso et al. reported PepT1-mediated KPV uptake and reduced NF-κB/MAP kinase signaling and pro-inflammatory cytokine secretion in human intestinal epithelial and immune cell lines. These findings do not establish direct binding of KPV to the p65 subunit. Kannengiesser et al. found effects that were at least partially independent of MC1R signaling in mouse colitis; they did not establish absence of binding to all melanocortin receptors.
Properties
CAS Number
67727-97-3
Molecular Formula
C₁₆H₃₀N₄O₄
Molecular Weight
342.43 Da
Sequence
Lys-Pro-Val
Half-Life
Not established
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- Independently tested by Bioviridian Inc. — identity by LC-MS/MS, purity by RP-HPLC (214 nm).
- Measured at 99.74% purity on lot KPV-20260828-01.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Research Applications
References & Citations
(3)PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al.
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Kannengiesser K, Maaser C, Heidemann J, et al.
Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases
Brzoska T, Luger TA, Maaser C, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.