KPV
10mg
KPV is a C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte stimulating hormone (α-MSH). Despite its minimal size, KPV retains the potent anti-inflammatory activity of the parent hormone while lacking its melanogenic and melanocortin receptor-dependent effects. KPV exerts anti-inflammatory action through a distinct, MC1R-independent mechanism, making it a unique tool for studying anti-inflammatory peptide signaling without melanocortin pathway engagement.
Pricing
Mechanism of Action
KPV inhibits NF-κB activation by directly entering cells and interacting with the p65 subunit of the NF-κB transcription factor, preventing nuclear translocation. This suppresses transcription of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6), chemokines, and adhesion molecules. KPV also inhibits inflammasome activation and reduces IL-8 production in intestinal epithelial cells. Notably, this mechanism does not require melanocortin receptor binding, distinguishing KPV from full-length α-MSH and other melanocortin peptides.
Properties
Molecular Formula
C₁₆H₃₀N₄O₄
Molecular Weight
342.43 Da
Sequence
Lys-Pro-Val
Half-Life
~30-60 minutes
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(2)Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Kannengiesser K, Maaser C, Heidemann J, et al.
α-Melanocyte-stimulating hormone and related tripeptides: biochemistry, anti-inflammatory and protective effects in vitro and in vivo
Brzoska T, Luger TA, Maaser C, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.