MOTS-c 10mg
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide encoded within the 12S rRNA of mitochondrial DNA. Discovered in 2015, MOTS-c is a 16-amino acid peptide that translocates to the nucleus upon metabolic stress and functions as a mitochondrial signaling molecule. It activates the AMPK pathway and regulates nuclear gene expression involved in substrate handling, insulin signaling, and cellular stress adaptation. MOTS-c levels decline with age, implicating it in metabolic-pathway and aging research. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Third-party tested to a 99%+ purity standard
Mechanism of Action
MOTS-c activates AMPK (AMP-activated protein kinase) by inhibiting the folate cycle and de novo purine synthesis, leading to AICAR accumulation. Nuclear translocation of MOTS-c enables direct interaction with transcription factors governing antioxidant response elements (ARE) and stress-response genes. In skeletal muscle, MOTS-c promotes insulin-independent GLUT4 translocation and upregulates oxidative phosphorylation complexes.
Properties
Molecular Formula
C₇₄H₁₃₁N₂₃O₂₃S
Molecular Weight
1754.0 Da
Sequence
MRWQEMGYIFYPRKLR
Half-Life
~10-30 minutes
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- Independently tested by accredited third-party laboratories.
- Held to a 99%+ purity standard.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Batch test records are published to each product as they are completed.
Research Applications
References & Citations
(1)Mitochondrially derived peptides as novel regulators of metabolism
Kim SJ, Xiao J, Wan J, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.