MOTS-c
10mg
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide encoded within the 12S rRNA of mitochondrial DNA. Discovered in 2015, MOTS-c is a 16-amino acid peptide that translocates to the nucleus upon metabolic stress and functions as a mitochondrial signaling molecule. It activates the AMPK pathway and regulates nuclear gene expression involved in glucose metabolism, insulin sensitivity, and cellular stress adaptation. MOTS-c levels decline with age and obesity, implicating it in metabolic disease and aging.
Pricing
Mechanism of Action
MOTS-c activates AMPK (AMP-activated protein kinase) by inhibiting the folate cycle and de novo purine synthesis, leading to AICAR accumulation. Nuclear translocation of MOTS-c enables direct interaction with transcription factors governing antioxidant response elements (ARE) and stress-response genes. In skeletal muscle, MOTS-c enhances glucose uptake independently of insulin by promoting GLUT4 translocation, and improves mitochondrial function by upregulating oxidative phosphorylation complexes.
Properties
Molecular Formula
C₇₄H₁₃₁N₂₃O₂₃S
Molecular Weight
1754.0 Da
Sequence
Mrwqemgyifyprklr
Half-Life
~10-30 minutes
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(2)The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, Zeng J, Drew BG, et al.
Mitochondrially derived peptides as novel regulators of metabolism
Kim SJ, Xiao J, Wan J, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.