NAD+ (Buffered) 500mg
Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme present in all living cells, functioning as an essential electron carrier in mitochondrial oxidative phosphorylation and as a substrate for sirtuins (SIRT1-7), PARPs, and CD38/CD157 ectoenzymes. Intracellular NAD+ levels decline significantly with age — by approximately 50% between ages 40-60 in human skin tissue — contributing to mitochondrial dysfunction, impaired DNA repair, and metabolic-pathway decline. This buffered lyophilized formulation is intended for research applications requiring direct NAD+ addition. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Third-party tested to a 99%+ purity standard
Mechanism of Action
NAD+ serves as a substrate for three major enzyme families: (1) Sirtuins — NAD+-dependent deacetylases that regulate mitochondrial biogenesis, DNA repair, inflammation, and metabolic adaptation; (2) PARPs — DNA damage repair enzymes that consume NAD+ during poly(ADP-ribosyl)ation; (3) CD38/CD157 — ectoenzymes involved in calcium signaling and immune function that represent the dominant NAD+ consumer in aging tissues. Restoring NAD+ levels in preclinical models improves mitochondrial function, activates SIRT1/SIRT3 signaling, enhances oxidative phosphorylation, and improves stem cell function.
Properties
Molecular Formula
C₂₁H₂₇N₇O₁₄P₂
Molecular Weight
663.43 Da
Storage
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C, use within 48 hours. Sensitive to degradation in solution.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- Independently tested by accredited third-party laboratories.
- Held to a 99%+ purity standard.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Batch test records are published to each product as they are completed.
Research Applications
References & Citations
(3)NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Yoshino J, Baur JA, Imai SI.
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Camacho-Pereira J, Tarragó MG, Chini CCS, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.