NAD+ (Buffered)
500mg
Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme present in all living cells, functioning as an essential electron carrier in mitochondrial oxidative phosphorylation and as a substrate for sirtuins (SIRT1-7), PARPs, and CD38/CD157 ectoenzymes. Intracellular NAD+ levels decline significantly with age — by approximately 50% between ages 40-60 in human skin tissue — contributing to mitochondrial dysfunction, impaired DNA repair, and metabolic decline. This buffered lyophilized formulation is optimized for research applications requiring direct NAD+ supplementation.
Pricing
Mechanism of Action
NAD+ serves as a substrate for three major enzyme families: (1) Sirtuins — NAD+-dependent deacetylases that regulate mitochondrial biogenesis, DNA repair, inflammation, and metabolic adaptation; (2) PARPs — DNA damage repair enzymes that consume NAD+ during poly(ADP-ribosyl)ation; (3) CD38/CD157 — ectoenzymes involved in calcium signaling and immune function that represent the dominant NAD+ consumer in aging tissues. Restoring NAD+ levels in preclinical models improves mitochondrial function, activates SIRT1/SIRT3 signaling, enhances oxidative phosphorylation, and improves stem cell function.
Properties
Molecular Formula
C₂₁H₂₇N₇O₁₄P₂
Molecular Weight
663.43 Da
Storage
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C, use within 48 hours. Sensitive to degradation in solution.
Research Applications
References & Citations
(3)NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Yoshino J, Baur JA, Imai SI.
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Camacho-Pereira J, Tarragó MG, Chini CCS, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.