PT-141 (Bremelanotide) 10mg
Bremelanotide (PT-141) is a cyclic heptapeptide melanocortin receptor agonist; structurally it is the C-terminal free-acid form of the Melanotan II scaffold. Zhang et al. (2021) determined a cryo-electron microscopy structure of bremelanotide bound to the melanocortin-4 receptor (MC4R) in complex with Gs protein. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Plain, secure packaging
- Certificates published per tested lot — see current coverage
- Stock-solution arithmetic — PT-141 concentration calculator
Mechanism of Action
Zhang et al. (2021) report that bremelanotide shares the conserved binding mode of peptidic agonists at MC4R. In ovariectomized, hormone-primed female rats, Pfaus et al. (2007) review that bremelanotide selectively increased solicitation behavior after peripheral administration or infusion into the lateral ventricles or medial preoptic area, but not the ventromedial hypothalamus; peripheral administration activated hypothalamic and limbic regions, and the authors suggest it may act through dopamine terminals in the medial preoptic area.
Properties
CAS Number
189691-06-3
Molecular Formula
C₅₀H₆₈N₁₄O₁₀
Molecular Weight
1025.17 Da
Sequence
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Half-Life
Not established
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 21 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(2)Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Zhang H, Chen LN, Yang D, et al.
Bremelanotide: an overview of preclinical CNS effects on female sexual function.
Pfaus J, Giuliano F, Gelez H.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.