CJC-1295 (No DAC)
10mg
CJC-1295 without Drug Affinity Complex (also known as modified GRF 1-29 or mod-GRF) is a synthetic 29-amino acid analog of growth hormone-releasing hormone (GHRH) with four amino acid substitutions that confer resistance to DPP-IV enzymatic degradation. Without the DAC (maleimidopropionic acid) conjugation that enables irreversible albumin binding, this form has a shorter half-life but produces more physiologic pulsatile GH release patterns, making it preferred for research protocols simulating natural GH secretion.
Pricing
Mechanism of Action
CJC-1295 (no DAC) binds the GHRH receptor on anterior pituitary somatotrophs, activating Gs-adenylyl cyclase-cAMP-PKA signaling to stimulate GH synthesis and secretion. The four amino acid modifications (Ala at positions 2, 8, 15; Leu at position 27) prevent DPP-IV cleavage between His-Ala at position 1-2, extending activity from ~7 minutes (native GHRH) to ~30 minutes. Without DAC, it does not sustain albumin binding, producing acute GH pulses rather than sustained GH elevation.
Properties
Molecular Weight
3367.97 Da
Half-Life
~30 minutes (without DAC)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(2)Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog
Ionescu M, Frohman LA.
Variability in anterior pituitary size within members of a GHRH receptor mutation kindred
Alba M, Fintini D, Salvatori R.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.