Compound monograph
CJC-1295
CJC-1295 designates a tetrasubstituted analog of human growth hormone-releasing factor residues 1 to 29, reported to act at the GRF receptor on the anterior pituitary.
01
Identity & nomenclature
CJC-1295 designates a tetrasubstituted analog of human growth hormone-releasing factor residues 1 to 29, reported to act at the GRF receptor on the anterior pituitary.
The name CJC-1295 is used in the literature and in commerce for two distinct species. The compound identified in the original report is a tetrasubstituted form of hGRF(1-29) bearing an N-epsilon-3-maleimidopropionamide derivative of lysine at the C-terminus; that maleimido group is the drug affinity complex, and it bioconjugates in vivo to the free thiol at Cys34 of serum albumin. Material sold as CJC-1295 without DAC lacks that linker and does not form the albumin conjugate. The PubChem record cited here (CID 91971820) corresponds to the form without the maleimido linker. Identity should be established against the intended species.
Declared aliases and development codes: CJC 1295.
02
Molecular properties
| Molecular formula | C165H269N47O46 |
|---|---|
| Molecular mass | 3647.2 Da |
| CAS Registry Number | 446262-90-4 |
| PubChem CID | 91971820 |
| UNII | 62RC32V9N7 |
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Structural characteristics
The original report describes synthesis of three maleimido derivatives of hGRF(1-29) and their ex vivo bioconjugation to human serum albumin, with all three conjugates showing enhanced in vitro stability against dipeptidyl peptidase IV. CJC-1295 was selected from that series.
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Molecular targets & mechanisms
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Analytical considerations
Because the DAC and non-DAC species differ by the maleimidopropionamide linker, mass-based identity methods distinguish them directly. A conjugated sample additionally carries albumin, which alters apparent mass by roughly the mass of serum albumin and requires a method that resolves the conjugate rather than the free peptide.
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Verified bibliography
- Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.current
Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP
Endocrinology · 2005-04-07 · Journal Article
- Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.current
Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R
American journal of physiology. Endocrinology and metabolism · 2006-07-05 · Journal Article
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.current
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA
The Journal of clinical endocrinology and metabolism · 2005-12-13 · Journal Article
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Methodology & citation verification
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