Research Article category
Laboratory Analysis & Quality
Laboratory methods for peptide identity, purity, stability, material form, certificates, and analytical interpretation.
7 published articles
Articles in this category
All Research ArticlesHow to Read a Peptide Certificate of Analysis (COA)
A practical, laboratory-focused guide to interpreting peptide COAs without confusing purity, identity, content, or method suitability.
What Does Lyophilized Mean? The Science of Freeze-Dried Peptides
Lyophilization is more than making a powder. It is a controlled freezing and drying process whose outcome depends on formulation, temperature, pressure, and residual moisture.
Why Peptide Stability Is Sequence-Dependent
Peptides do not share one universal stability profile. Their sequences create different vulnerabilities to oxidation, deamidation, hydrolysis, adsorption, and aggregation.
Peptide Purity and Identity: Understanding HPLC, Mass Spectrometry, and Certificates of Analysis
Purity, identity, and quantity are three different questions. Here is what HPLC can answer, what mass spectrometry can answer, and why one number cannot describe a peptide material.
Certificate of Analysis vs. Safety Data Sheet: What Is the Difference?
A CoA is an analytical document. An SDS is a hazard-communication document. Neither substitutes for the other, and neither answers every question about a peptide material.
Peptide Salts and Counterions: What Do Acetate, TFA, and Hydrochloride Mean?
Acetate, trifluoroacetate, and chloride are not interchangeable labels. They contribute different amounts of mass and can change analytical behavior and sample preparation.
HPLC Purity vs. Peptide Content: Why the Percentages Can Be Different
A material can be 98.7% pure by HPLC and still be only 76% peptide by mass. The two numbers are not contradictory - they answer different questions.