Research Article category
Metabolic Research
Research articles covering incretin receptors, mitochondrial signaling, cellular energy pathways, and metabolic pharmacology.
4 published articles
Articles in this category
All Research ArticlesTirzepatide vs Semaglutide: Comparative Analysis of Incretin Receptor Pharmacology
Tirzepatide's dual agonism at GLP-1 and GIP receptors gives it a mechanistically distinct profile from semaglutide's selective GLP-1 activity. Here we compare receptor pharmacology, published trial outcomes, and the synergistic mechanisms of the twincretin class.
Retatrutide: Triple Incretin Receptor Agonism and the Next Frontier of Metabolic Research
Retatrutide (LY3437943) is a single molecule that simultaneously agonizes the GLP-1, GIP, and glucagon receptors. Phase 2 data published in 2023 reported dose-dependent body-composition endpoints, establishing triagonism as a distinct pharmacological class.
MOTS-c: A Mitochondrial-Derived Peptide in Metabolic-Pathway Research
MOTS-c is one of a small class of mitochondrial-derived peptides encoded within mtDNA. This overview surveys its origin, AMPK-linked signaling, and the preclinical models in which it is studied.
NAD+ in Cellular Metabolism, Sirtuin, and DNA-Repair Research
NAD+ is a central redox coenzyme and a substrate for sirtuins and PARPs. This overview surveys the pathways in which it is studied, from the salvage cycle to mitochondrial and DNA-repair research.