5-Amino-1MQ 10mg
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule methylquinolinium compound, not a peptide, studied as an inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide to 1-methylnicotinamide (1-MNA) using S-adenosylmethionine (SAM). This listing contains 10mg of lyophilized material. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Certificates published per tested lot — see current coverage
Mechanism of Action
Neelakantan et al. (2018) characterized a series of membrane-permeable methylquinolinium NNMT inhibitors, the scaffold class that includes 5-amino-1MQ. The inhibitors did not inhibit related SAM-dependent methyltransferases or NAD+ salvage-pathway enzymes, and in cultured adipocytes they reduced intracellular 1-MNA, increased intracellular NAD+ and SAM, and suppressed lipogenesis. The study also reported reduced white adipose mass in a diet-induced obese mouse model treated with a potent inhibitor from the series; that mouse finding does not establish effects outside the model.
Properties
CAS Number
42464-96-0
Molecular Formula
C₁₀H₁₁IN₂ (iodide salt)
Molecular Weight
286.11 Da (iodide salt)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(1)Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.
Neelakantan H, Vance V, Wetzel MD, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.