ARA-290 (Cibinetide)
10mg
ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide corresponding to the helix-B surface region of erythropoietin (EPO). It is a non-erythropoietic, non-hematopoietic EPO derivative that selectively engages the innate repair receptor (IRR) — the heteromeric EPO-receptor / β-common-receptor (EPOR-βcR) complex — without stimulating erythropoiesis, making it a tool for isolating the tissue-protective arm of EPO signaling. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Third-party tested to a 99%+ purity standard
Mechanism of Action
ARA-290 selectively activates the innate repair receptor (EPOR-βcR complex) expressed in response to injury and metabolic stress, without binding the homodimeric EPO receptor that drives red-cell production. IRR activation engages pro-survival signaling (Akt, eNOS), modulates VEGF, and attenuates pro-inflammatory cytokine expression (IL-1β, TNF-α) in preclinical injury models, dissociating tissue-protective signaling from the erythropoietic effects of native EPO.
Properties
Molecular Formula
C₅₅H₈₅N₁₇O₂₃
Molecular Weight
1257.36 Da
Sequence
Gln-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
Half-Life
~2 minutes (rapid plasma clearance; preclinical)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- Independently tested by accredited third-party laboratories.
- Held to a 99%+ purity standard.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Batch test records are published to each product as they are completed.
Research Applications
References & Citations
(3)Activation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes
Bitto A, Irrera N, Pizzino G, et al.
The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic
O'Leary OE, Canning P, Reid E, et al.
Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand
Yao M, Watanabe M, Sun S, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.