ARA-290 (Cibinetide) 10mg
ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide corresponding to the helix-B surface region of erythropoietin (EPO), bearing an N-terminal pyroglutamate. The pyroglutamate is definitional rather than incidental: the free-glutamine parent peptide (HBSP, CAS 924902-90-9) is a separate compound, and cibinetide / CAS 1208243-50-8 denotes specifically the cyclized pyroglutamate form (pHBSP). It is a non-erythropoietic, non-hematopoietic EPO derivative that is reported to act through the proposed innate repair receptor (IRR), a heteromeric EPO-receptor / β-common-receptor (EPOR-βcR) complex whose structure has not been confirmed, without stimulating erythropoiesis, making it a tool for isolating the tissue-protective arm of EPO signaling. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
Select Option
2+ save 5% · 5+ save 10% · 10+ save 20%
- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Plain, secure packaging
- Certificates published per tested lot — see current coverage
- Stock-solution arithmetic — ARA-290 concentration calculator
Mechanism of Action
ARA-290 is reported to activate the proposed innate repair receptor (EPOR-βcR complex) expressed in response to injury and metabolic stress, without binding the homodimeric EPO receptor that drives red-cell production. IRR activation engages pro-survival signaling (Akt, eNOS), modulates VEGF, and attenuates pro-inflammatory cytokine expression (IL-1β, TNF-α) in preclinical injury models, dissociating tissue-protective signaling from the erythropoietic effects of native EPO.
Properties
CAS Number
1208243-50-8
Molecular Formula
C₅₁H₈₄N₁₆O₂₁
Molecular Weight
1257.32 Da
Sequence
pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
Half-Life
~2 min (rat and rabbit plasma)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(4)Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin.
Brines M, Patel NS, Villa P, Brines C, Mennini T, De Paola M, Erbayraktar Z, Erbayraktar S, Sepodes B, Thiemermann C, Ghezzi P, Yamin M, Hand CC, Xie QW, Coleman T, Cerami A
Activation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes
Bitto A, Irrera N, Pizzino G, et al.
The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic
O'Leary OE, Canning P, Reid E, et al.
Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand
Yao M, Watanabe M, Sun S, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.