Melanotan-I 10mg
Melanotan-I ([Nle⁴,D-Phe⁷]-α-MSH, afamelanotide) is a linear 13-residue analog of α-melanocyte-stimulating hormone. Two substitutions — norleucine at position 4 and D-phenylalanine at position 7 — slow enzymatic degradation and increase melanocortin-1 receptor binding relative to native α-MSH. It is the linear parent of the better-known cyclic Melanotan-II, and the two are distinct compounds that supplier catalogs frequently confuse. This listing contains 10mg of lyophilized material. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Plain, secure packaging
- Certificates published per tested lot — see current coverage
Mechanism of Action
Melanotan-I is a melanocortin-1 receptor agonist. Sawyer et al. (1980) described the [Nle⁴,D-Phe⁷] substitution and reported prolonged activity and resistance to enzymatic degradation relative to α-MSH in frog and lizard skin bioassays. Receptor engagement at MC1R activates adenylate cyclase and downstream eumelanin synthesis in melanocytes.
Properties
CAS Number
75921-69-6
Molecular Formula
C78H111N21O19
Molecular Weight
1646.85 Da
Sequence
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂
Half-Life
Not established
Storage
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(1)4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity
Sawyer TK, Sanfilippo PJ, Hruby VJ, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.