MT-2 (Melanotan-II) 10mg
Melanotan-II (MT-2) is a cyclic lactam analog of alpha-melanocyte stimulating hormone (α-MSH). Developed at the University of Arizona, MT-2 is a non-selective melanocortin receptor agonist with activity at MC1R, MC3R, MC4R, and MC5R subtypes. It was originally investigated for melanogenesis stimulation and is studied across melanocortin-receptor pharmacology, MC4R arousal-circuit signaling, and feeding-circuit and reward-behavior models due to its receptor promiscuity. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Plain, secure packaging
- Certificates published per tested lot — see current coverage
- Stock-solution arithmetic — Melanotan II concentration calculator
Mechanism of Action
MT-2 binds MC1R, MC3R, MC4R, and MC5R with varying affinity in vitro (Doedens et al., 2010). MC1R activation on melanocytes upregulates tyrosinase and melanin synthesis via cAMP/PKA signaling. MC4R activation in hypothalamic nuclei modulates MC4R arousal-circuit signaling and feeding-circuit pathways studied in preclinical models. MC3R engagement influences energy-metabolism signaling and lipid partitioning. The cyclic structure of MT-2 (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂) provides enhanced receptor binding affinity and enzymatic resistance over linear α-MSH.
Properties
CAS Number
121062-08-6
Molecular Formula
C₅₀H₆₉N₁₅O₉
Molecular Weight
1024.18 Da
Sequence
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Half-Life
Not established
Storage
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C, use within 21 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(2)Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics
Al-Obeidi F, Castrucci AM, Hadley ME, et al.
Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies
Doedens L, Opperer F, Cai M, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.