PE 22-28
10mg
PE 22-28 is a synthetic peptide fragment derived from spexin (SPX), a 14-amino-acid neuropeptide first identified by bioinformatics and encoded by the C12orf39 gene. PE 22-28 corresponds to a spexin-based sequence retaining activity at galanin receptor subtypes and is studied as a receptor-pharmacology tool for the spexin/galanin/kisspeptin system. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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2+ save 5% · 5+ save 10% · 10+ save 20%
- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Third-party tested to a 99%+ purity standard
Mechanism of Action
Spexin and its fragments act as endogenous ligands for galanin receptor types 2 and 3 (GALR2/GALR3), rhodopsin-like G-protein-coupled receptors, with markedly higher potency at GALR3 than galanin itself and little activity at GALR1. In research models this receptor engagement is studied for central signaling relevant to energy-metabolism regulation and adipocyte fatty-acid handling, and spexin expression is strongly downregulated in obese adipose tissue. PE 22-28 is used to probe these GALR2/3-mediated pathways.
Properties
Half-Life
~short (peptide fragment; preclinical)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- Independently tested by accredited third-party laboratories.
- Held to a 99%+ purity standard.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Batch test records are published to each product as they are completed.
Research Applications
References & Citations
(2)Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity
Walewski JL, Ge F, Lobdell H, et al.
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III
Kim DK, Yun S, Son GH, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.