SNAP-8
10mg
SNAP-8 (acetyl octapeptide-3) is a synthetic octapeptide that mimics the N-terminal domain of SNAP-25 (synaptosomal-associated protein of 25 kDa), one of the three SNARE complex proteins required for vesicular neurotransmitter release. It is an extension of the hexapeptide acetyl hexapeptide-3 (Argireline) with two additional amino acids, providing enhanced potency. SNAP-8 is primarily investigated in dermatological research as a topical neuropeptide for expression line modulation.
Pricing
Mechanism of Action
SNAP-8 competitively inhibits SNARE complex assembly by mimicking the SNAP-25 protein, thereby attenuating vesicular acetylcholine release at the neuromuscular junction of facial muscles. By reducing the efficiency of synaptic vesicle docking and fusion, SNAP-8 decreases the intensity of muscle contraction underlying expression lines. Unlike botulinum toxin (which cleaves SNARE proteins proteolytically and irreversibly), SNAP-8 acts as a reversible competitive antagonist.
Properties
Molecular Formula
C₄₁H₇₀N₁₆O₁₆S
Molecular Weight
1075.16 Da
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
Half-Life
~4-6 hours (topical application dependent)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(2)A synthetic hexapeptide (Argireline) with antiwrinkle activity
Blanes-Mira C, Clemente J, Jodas G, et al.
SNAP-8 peptide solution: A next-generation anti-wrinkle peptide
Lipotec S.A.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.