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Catalog/Thymosin Beta-4 (TB-500)
Thymosin Beta-4 (TB-500)
#1055
Lyophilized Peptide

Thymosin Beta-4 (TB-500) 10mg

Thymosin beta-4 (Tβ4, timbetasin) is a 43-residue peptide, N-acetylated at Ser1 with a free C-terminal carboxyl. This listing is sold under the TB-500 name and is the full-length 43-residue peptide, not the seven-residue Ac-LKKTETQ fragment that the TB-500 designation can also refer to. This listing contains 10mg of lyophilized material. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.

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Single (10mg)$67.95

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1
= $67.95
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  • Ships same day on orders before 2 PM MST
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  • Certificates published per tested lot — see current coverage

Mechanism of Action

Hannappel (2007) reviews the beta-thymosins as the main intracellular G-actin-sequestering peptides. Hannappel (2010) reviews the post-translational modifications described for thymosin beta-4.

Properties

CAS Number

77591-33-4

Molecular Formula

C212H350N56O78S

Molecular Weight

4963.5 Da

Sequence

Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser

Storage

Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.

Shipping & Delivery

  • Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
  • US shipping from $5. Free Priority on orders $100+ (before discounts).
  • Plain, unmarked packaging — no branding or product names on the outside.
  • Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
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Quality & Testing

  • No third-party certificate has been published for this compound yet.
  • USA-based; dispatched from Phoenix, Arizona.
  • Supplied strictly for in-vitro laboratory research — not for human use.

Certificates are published for each lot we have tested — see the 14 published so far.

Research Applications

1G-actin binding and actin-sequestration studies
2Analysis of thymosin beta-4 post-translational modifications
3Comparisons of full-length thymosin beta-4 with its fragments

References & Citations

(2)
1

beta-Thymosins.

Hannappel E.

Ann N Y Acad Sci (2007)PMID: 17468232 DOI
2

Thymosin beta4 and its posttranslational modifications.

Hannappel E.

Ann N Y Acad Sci (2010)PMID: 20536447 DOI

Research Use Only

This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.

Research reference

A published identity, mechanism, and bibliography record corresponds to this catalog entry.

Research reference: Thymosin beta-4

More references from the Research Library (5)

Further papers cited in the Library's Thymosin beta-4 record, each checked against PubMed. They describe the compound in research settings and are not statements about this product. See the full record for its identity, structure and complete bibliography.

  1. Actin dynamics.

    Pollard TD, Blanchoin L, Mullins RD

    Journal of cell science (2001)Study type not determinedPMID 11112680
  2. The beta-thymosin enigma.

    Sun HQ, Yin HL

    Annals of the New York Academy of Sciences (2007)Review articlePMID 17495248
  3. The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase.

    Kumar N, Nakagawa P, Janic B, et al.

    American journal of physiology. Renal physiology (2016)In vitro · AnimalPMID 26962108
  4. Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP.

    Cavasin MA, Rhaleb NE, Yang XP, et al.

    Hypertension (Dallas, Tex. : 1979) (2004)In vitro · AnimalPMID 15037553
  5. Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis.

    Zuo Y, Chun B, Potthoff SA, et al.

    Kidney international (2013)AnimalPMID 23739235