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Research Catalog

parent and analog

Cagrilintide vs Amylin (human IAPP)

Cagrilintide is an acylated amylin analog with residue substitutions. The two records share a disulfide-linked peptide scaffold but describe distinct molecules.

Published: 2026-10-03Library record comparison: 2026-10-03

01

Identity side by side

Recorded molecular identities of Cagrilintide and Amylin (human IAPP)
Recorded fieldCagrilintideAmylin (human IAPP)
Canonical nameCagrilintideAmylin
AliasesAM833; AM-833Human islet amyloid polypeptide; IAPP; hIAPP; Amlintide
Development codesNNC0174-0833not recorded
CAS1415456-99-3122384-88-7
UNIIAO43BIF1U8U3U3114NE1
PubChem CID17139705416132430
Molecular formulaC194H312N54O59S2C165H261N51O55S2
Molecular weight (Da)4409.013903.3
Sequence length (residues)3737
Terminal modificationsC-terminal amide; N-terminal acylation via gamma-glutamyl linkerC-terminal amide at Tyr37
Structural modificationsCys2–Cys7 disulfide; C20 dicarboxylic fatty-acid acylationCys2-Cys7 disulfide

Cagrilintide: nomenclature notes

An FDA substance record displays C194H312N54O58S2 against an approximately 4409 Da mass. That oxygen count is inconsistent with both the stated mass and the covalent structure; reconstruction gives O59, matching PubChem. The O58 value is 15.9949 Da lighter and is not a salt or protonation difference. This library records O59 and notes the disagreement rather than silently choosing.

Amylin (human IAPP): nomenclature notes

Amylin and IAPP are the same molecule under two names when both refer to this mature human peptide. They are NOT synonyms for the IAPP gene, for proIAPP, for a processing intermediate, for the reduced peptide, or for rodent amylin — rat amylin differs in sequence and is a common substitute in structural work. The FDA substance record uses 'amlintide' as a preferred name for this peptide; amlintide is NOT pramlintide, which carries three proline substitutions and is a separate entry in this library.

02

Residue sequence comparison

Positions are numbered from each stored sequence’s first residue. Highlighted cells differ or extend beyond the other chain; a dash indicates no aligned residue. One-letter notation does not encode terminal groups or stereochemistry. Read the recorded notes below.

Aligned one-letter residue sequences
Cagrilintide1K2C3N4T5A6T7C8A9T10Q11R12L13A14E15F16L17R18H19S20S21N22N23F24G25P26I27L28P29P30T31N32V33G34S35N36T37P
Amylin (human IAPP)1K2C3N4T5A6T7C8A9T10Q11R12L13A14N15F16L17V18H19S20S21N22N23F24G25A26I27L28S29S30T31N32V33G34S35N36T37Y

Differences in text

  • Cagrilintide: residue 14 = E; Amylin (human IAPP): residue 14 = N.
  • Cagrilintide: residue 17 = R; Amylin (human IAPP): residue 17 = V.
  • Cagrilintide: residue 25 = P; Amylin (human IAPP): residue 25 = A.
  • Cagrilintide: residue 28 = P; Amylin (human IAPP): residue 28 = S.
  • Cagrilintide: residue 29 = P; Amylin (human IAPP): residue 29 = S.
  • Cagrilintide: residue 37 = P; Amylin (human IAPP): residue 37 = Y.

Cagrilintide

Terminal modifications
C-terminal amide; N-terminal acylation via gamma-glutamyl linker
Structural modifications
Cys2–Cys7 disulfide; C20 dicarboxylic fatty-acid acylation
Sequence notes
Thirty-seven residues with a Cys2–Cys7 disulfide and a C-terminal amide. The backbone string alone is an incomplete description: the N-terminal lysine carries a gamma-glutamyl linker acylated with a C20 dicarboxylic fatty acid, attached at the alpha-amino group rather than the lysine side chain.

Amylin (human IAPP)

Terminal modifications
C-terminal amide at Tyr37
Structural modifications
Cys2-Cys7 disulfide
Sequence notes
Thirty-seven residues with a Cys2-Cys7 disulfide and a C-terminal Tyr37 amide. The backbone string alone is not a complete description: both the disulfide and the amide are required, and neither is visible in a linear sequence.

03

Recorded mechanisms

These lists show the links recorded in each monograph. An unlisted link does not establish its absence from the molecule’s biology.

Shared recorded links

Recorded only for Cagrilintide

not recorded

Recorded only for Amylin (human IAPP)

not recorded

04

Recorded compound classes

Recorded only for Cagrilintide

not recorded

Recorded only for Amylin (human IAPP)

not recorded

05

References for the relationship

  1. Development of Cagrilintide, a Long-Acting Amylin Analogue.

    Kruse T, Hansen JL, Dahl K, Schäffer L, Sensfuss U, Poulsen C, Schlein M, Hansen AMK, Jeppesen CB, Dornonville de la Cour C, Clausen TR, Johansson E, Fulle S, Skyggebjerg RB, Raun K

    Journal of medicinal chemistry · 2021-07-21 · Journal Article

    current
    PMID 34288673DOI 10.1021/acs.jmedchem.1c00565CagrilintideAmylin (human IAPP)PramlintideCALCR

06

Read the full monographs

Cagrilintide →Amylin (human IAPP) →