Amylin and calcitonin receptor agonists

Compound

Amylin (human IAPP)

Amylin is the endogenous 37-residue human pancreatic peptide hormone, co-secreted with insulin, from which pramlintide and cagrilintide are both derived.

Human islet amyloid polypeptide · IAPP · hIAPP · Amlintide

Compound

Cagrilintide

Cagrilintide is a long-acting synthetic amylin analog, lipidated and disulfide-cyclized, characterised at the calcitonin receptor and at amylin receptor complexes.

AM833 · AM-833 · NNC0174-0833

Compound

Pramlintide

Pramlintide is an engineered analog of human amylin carrying three proline substitutions, designed to address the aggregation behaviour of the native human sequence.

AC137

receptor

Amylin and calcitonin receptors

The calcitonin receptor, and the amylin receptor complexes it forms when associated with receptor activity-modifying proteins RAMP1, RAMP2 or RAMP3. Because the amylin receptors are heteromers rather than distinct gene products, receptor construct and accessory-protein expression must accompany any selectivity claim; a potency ranking is not transferable between assay systems.