Adipotide 5mg
This 5mg vial is the larger of the two adipotide strengths stocked. Adipotide (FTPP, fat-targeted proapoptotic peptide) is a chimeric synthetic peptide joining a cyclic prohibitin-targeting sequence to a D-amino-acid proapoptotic domain. The targeting half was identified by phage display as binding prohibitin on the vasculature of white adipose tissue; the effector half is a D(KLAKLAK)₂ sequence that disrupts mitochondrial membranes once internalized. The published work is in mouse and non-human primate models. This listing contains 5mg of lyophilized material. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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2+ save 5% · 5+ save 10% · 10+ save 20%
- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Plain, secure packaging
- Certificates published per tested lot — see current coverage
Mechanism of Action
Kolonin et al. (2004) used phage display to identify a peptide binding prohibitin in white adipose vasculature, fused it to a D(KLAKLAK)₂ proapoptotic domain, and reported ablation of adipose vasculature in obese mice. Barnhart et al. (2011) reported the same construct in obese rhesus monkeys. The construct is designed so the effector domain is inactive until the targeting domain concentrates it at the endothelial surface.
Properties
CAS Number
859216-15-2
Molecular Weight
2611.41 Da
Half-Life
Not established
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(2)Reversal of obesity by targeted ablation of adipose tissue
Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W.
A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys
Barnhart KF, Christianson DR, Hanley PW, et al.
Other strengths
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.