Epithalon
10mg
Epithalon (epitalon, epithalone) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin, which is produced by the pineal gland. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, epithalon is the most extensively studied member of the Khavinson peptide bioregulator family. Research has focused on its telomerase-activating properties and potential role in cellular senescence modulation.
Pricing
Mechanism of Action
Epithalon activates telomerase, the ribonucleoprotein enzyme responsible for maintaining telomere length during cell division. By upregulating the catalytic subunit hTERT (human telomerase reverse transcriptase), epithalon may counteract the progressive telomere shortening associated with replicative senescence. Additionally, research suggests epithalon modulates pineal gland function, normalizing circadian melatonin secretion patterns in aging models and potentially influencing antioxidant enzyme expression (SOD, glutathione peroxidase).
Properties
Molecular Formula
C₁₄H₂₂N₄O₉
Molecular Weight
390.35 Da
Sequence
Ala-Glu-Asp-Gly
Half-Life
~30 minutes
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(3)Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Khavinson VK, Bondarev IE, Butyugov AA.
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice
Anisimov VN, Khavinson VKh, Popovich IG, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.