Compound monograph
Epitalon
Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, described in the source literature as a short peptide designed following work on pineal tissue extracts.
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Identity & nomenclature
Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, described in the source literature as a short peptide designed following work on pineal tissue extracts.
Epitalon, Epithalon, and Epithalone all refer to the same tetrapeptide. A second registry number, 64082-79-7, also appears in the PubChem record; 307297-39-8 is carried here as primary. The literature describes the peptide as having been designed following work on a pineal extract preparation named Epithalamin, from which the name derives.
Declared aliases and development codes: Epithalon, Epithalone, AEDG peptide.
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Molecular properties
| Molecular formula | C14H22N4O9 |
|---|---|
| Molecular mass | 390.35 Da |
| CAS Registry Number | 307297-39-8 |
| PubChem CID | 219042 |
| UNII | O65P17785G |
| One-letter sequence | AEDG |
| Three-letter sequence | Ala–Glu–Asp–Gly |
| Terminal groups | Free N-terminus; Free C-terminal carboxyl |
Tetrapeptide Ala-Glu-Asp-Gly, stated identically in the PubChem synonym record and in the source literature.
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Structural characteristics
The sequence comprises four proteinogenic residues with no reported terminal modification in the PubChem record. Two of the four side chains are acidic, giving the peptide a low isoelectric point relative to neutral tetrapeptides.
Terminal features: Free N-terminus, Free C-terminal carboxyl.
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Molecular targets & mechanisms
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Analytical considerations
At 390 Da this is among the smallest peptides in the catalog, and it contains no aromatic residues, so UV detection at 280 nm gives no useful chromophore response. Identity confirmation relies on mass and sequence-level methods.
Disagreements and mix-ups
Points where sources disagree about this compound's identity, or where a name or form is easily confused with another, as noted in this record. The discrepancy register quotes the passage for each one.
Sources disagree · this Library follows one source · Registry number
Two CAS numbers attached to epitalon
What the studies reported
Each finding describes one cited study in its stated model. These observations are specific to that study and do not establish effects in other settings.
Cell and tissue studies
Telomerase-negative human fetal fibroblast culture
Khavinson et al. reported expression of the telomerase catalytic subunit and telomerase enzymatic activity after adding Epithalon to telomerase-negative human fetal fibroblast culture.
Reference [3]Telomerase-negative human fetal fibroblast culture
Khavinson et al. reported telomere elongation after adding Epithalon to telomerase-negative human fetal fibroblast culture.
Reference [3]
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Verified bibliography
Cited studies by type
The 3 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.
A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.
Reference 1
currentReference 2
Peptide Regulation of Cell Differentiation.Khavinson V, Linkova N, Diatlova A, Trofimova S
Stem cell reviews and reports · 2020-02 · Review
currentReference 3
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.Khavinson VKh, Bondarev IE, Butyugov AA
Bulletin of experimental biology and medicine · 2003-06 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Khavinson VKh 2002 | Review article |
| Khavinson V et al. 2020 | Review article |
| Khavinson VKh et al. 2003 | Study models reported: in vitro · from the abstract |
Record history
Published 2026-09-04.
- : References
- : Sequence and structure
- : Identity and nomenclature
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Epitalon. Published 2026-09-04; updated 2026-10-16. https://purelypeptides.org/research/compounds/epitalon/
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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