P21 10mg
P21 is a synthetic peptide analog derived from CNTF (ciliary neurotrophic factor). The cited review describes the studied compound P021 as Ac-DGGLAG-NH2, with an adamantylated glycine group added to a CNTF-derived peptide. It reports blood-brain-barrier permeability for P021, but does not establish absence of antigenicity. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Ships same day on orders before 2 PM MST
- Plain, secure packaging
- Certificates published per tested lot — see current coverage
Mechanism of Action
Kazim and Iqbal review enhanced dentate-gyrus neurogenesis and BDNF expression with P021 in rodent studies, including aged Fisher rats and 3xTg-AD mice. They describe inhibition of LIF signaling as part of the proposed neurogenic mechanism for P021. In 3xTg-AD mice, the review links reduced tau hyperphosphorylation to increased BDNF and inhibition of GSK-3β activity.
Properties
CAS Number
1246751-68-7
Molecular Formula
C₂₇H₄₂N₆O₈
Molecular Weight
578.67 Da
Sequence
Ac-Asp-Gly-Gly-Leu-NH-(3-carbamoyl-1-adamantyl)
Half-Life
Not established
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(1)Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease
Kazim SF, Iqbal K.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.