P21 10mg
P21 (P021) is a synthetic peptidergic compound derived from ciliary neurotrophic factor (CNTF). Li et al. (2010) describe it as Ac-DGGLAG-NH2; in that shorthand, "AG" denotes a single adamantane-derived unit, not alanine followed by glycine. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Plain, secure packaging
- Certificates published per tested lot — see current coverage
- Stock-solution arithmetic — P21 concentration calculator
Mechanism of Action
Li et al. (2010) report that peripherally administered P21 increased neurogenesis and the maturation of newly born neurons in the dentate gyrus of normal adult mice. In 3xTg-AD mice fed P021 for 12 months, Kazim et al. (2014) report reduced abnormal tau hyperphosphorylation and accumulation and a more limited effect on amyloid-beta measures, which they link to increased BDNF expression and decreased GSK-3β activity.
Properties
CAS Number
1246751-68-7
Molecular Formula
C₂₇H₄₂N₆O₈
Molecular Weight
578.67 Da
Sequence
Ac-Asp-Gly-Gly-Leu-NH-(3-carbamoyl-1-adamantyl)
Half-Life
Not established
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(2)Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice
Li B, Wanka L, Blanchard J, et al.
Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease
Kazim SF, Blanchard J, Dai CL, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.