P21
10mg
P21 is a synthetic peptide analog derived from CNTF (ciliary neurotrophic factor), specifically designed to cross the blood-brain barrier and mimic the neurotrophic effects of CNTF without its antigenic properties. P21 contains four ciliary neurotrophic factor active region residues attached to a protein transduction domain (adamantane-based). It was developed to address the translational limitations of full-length CNTF, which cannot cross the BBB and elicits neutralizing antibody responses on repeated administration.
Pricing
Mechanism of Action
P21 enhances neurogenesis in the hippocampal dentate gyrus by increasing brain-derived neurotrophic factor (BDNF) expression and promoting dendritic complexity of newborn neurons. It partially inhibits leukemia inhibitory factor (LIF) signaling, reducing the gliogenic fate of neural progenitor cells while favoring neuronal differentiation. In Alzheimer's disease models, P21 reduced tau hyperphosphorylation by modulating GSK-3β activity and decreased amyloid plaque-associated neuroinflammation.
Properties
Molecular Weight
~1500 Da (approx.)
Half-Life
~2-4 hours
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(2)An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide
Bolognin S, Blanchard J, Wang X, et al.
Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease
Kazim SF, Iqbal K.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.