Controlled taxonomy
Compound Classes
A controlled, chemistry-first taxonomy of the compound classes represented in Purely Peptides Research.
Compound class
Amylin and calcitonin receptor agonists
Peptides that engage the calcitonin receptor and the amylin receptor complexes it forms with receptor activity-modifying proteins. Described as amylin analogs, they are not amylin-receptor-exclusive.
3 published compounds
Compound class
Copper-binding peptides
Peptides whose defining chemical feature is high-affinity coordination of Cu(II), forming discrete metal-peptide complexes with molecular identities distinct from the free peptide.
2 published compounds
Compound class
Cyclic melanocortin analogs
Synthetic melanocortin receptor ligands closed into a macrocycle by a side-chain to side-chain bridge, in contrast to the linear fragment and full-length melanocortin peptides.
4 published compounds
Compound class
GHRH analogs
Synthetic analogs of growth hormone-releasing factor, typically modified fragments of the 44-residue human sequence, acting at the GHRH receptor.
3 published compounds
Compound class
GLP-1 receptor peptide analogs
Designed peptide analogs whose declared molecular relationship is agonism at the glucagon-like peptide-1 receptor.
3 published compounds
Compound class
Growth hormone secretagogues
Endogenous peptide ligands, synthetic peptides and nonpeptide mimetics acting at the growth hormone secretagogue receptor (the ghrelin receptor), a distinct receptor from the GHRH receptor targeted by GHRH analogs.
7 published compounds
Compound class
Incretin and glucagon receptor ligands
Endogenous hormones acting at the GLP-1, GIP and glucagon receptors, held together without any claim of common chemical ancestry. It exists so native hormones are not filed in a class of analogs of themselves.
5 published compounds
Compound class
Kisspeptins
Peptides derived from the KISS1 precursor that share a C-terminal RF-amide motif and bind the kisspeptin receptor.
1 published compound
Compound class
Linear melanocortin analogs
Full-length melanocortin peptide analogs that retain a linear backbone, distinguished from the cyclic lactam analogs and from the short melanocortin fragments.
1 published compound
Compound class
Matrikine-derived peptides
Peptides corresponding to fragments of extracellular matrix proteins, typically studied for their reported effects on matrix synthesis in fibroblast culture.
5 published compounds
Compound class
Melanocortin fragment peptides
Short peptides corresponding to fragments of melanocortin hormones, retaining part of the parent sequence while lacking the residues required for melanocortin receptor binding.
2 published compounds
Compound class
Melanocortin receptor ligands
An umbrella for everything that acts at the melanocortin receptors regardless of chemistry — the native hormones, their fragments, cyclic analogs and nonpeptide small molecules. It exists so the native hormone is not filed as an analog of itself and a nonpeptide is not filed in a peptide class.
5 published compounds
Compound class
Mitochondrial-derived peptides
Peptides encoded by short open reading frames within the mitochondrial genome rather than the nuclear genome.
1 published compound
Compound class
Multi-receptor incretin analogs
Single peptide molecules characterized against more than one receptor in the incretin and glucagon receptor families.
4 published compounds
Compound class
Neurotrophic peptide mimetics
Small synthetic peptides designed to mimic regions of neurotrophic factors, typically characterised through downstream pathway readouts rather than a demonstrated direct receptor target.
1 published compound
Compound class
Nonpeptide receptor agonists
Small molecules characterized as agonists at receptors whose endogenous ligands are peptides, included here for comparison with the peptide agonists at the same receptor.
1 published compound
Compound class
Regenerative peptides
Synthetic peptides studied in connective-tissue and epithelial repair models, grouped by shared experimental context rather than by a common receptor.
1 published compound
Compound class
Regulatory peptide fragment analogs
Short synthetic peptides constructed from a fragment of a larger endogenous regulatory peptide, commonly extended with a stabilizing C-terminal sequence.
3 published compounds
Compound class
Thymosin-related peptides
Peptides originally isolated from thymic tissue fractions, subsequently characterized as having functions unrelated to thymic hormone activity.
2 published compounds