Compound class

Aromatic cationic tetrapeptides

Synthetic linear tetrapeptide amides with alternating aromatic residues and basic amino-acid residues, in either aromatic–basic–aromatic–basic or basic–aromatic–basic–aromatic order.

Published: 2026-09-28Literature/identifier verification: 2026-09-28

Neutral class definition

Synthetic linear tetrapeptide amides with alternating aromatic residues and basic amino-acid residues, in either aromatic–basic–aromatic–basic or basic–aromatic–basic–aromatic order.

Related compounds

Compound

Elamipretide

Elamipretide is a synthetic linear tetrapeptide with D-arginine, L-2′,6′-dimethyltyrosine, L-lysine and L-phenylalanine in that order, a free N-terminal amino group and a C-terminal primary carboxamide.

Bendavia · SS-31

Related molecular mechanisms

No published mechanisms are currently linked to this category.

Relevant glossary terms

Agonist Ligand G-protein-coupled receptor Peptide analog Lipidation Amidation

Verified bibliography

Reference 1
Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds.
Mitchell W, Tamucci JD, Ng EL, Liu S, Birk AV, Szeto HH, May ER, Alexandrescu AT, Alder NN
eLife · 2022-08-01 · Journal Article
current
PMID 35913044 PMC9342957 DOI 10.7554/eLife.75531 Elamipretide

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

Reference	Study models
Mitchell W et al. 2022	Study models reported: in vitro · from the abstract