Copper-binding peptides

Compound

GHK (Prezatide)

GHK is the uncomplexed tripeptide ligand of the GHK-copper complex, identified in 1977 as a growth-modulating tripeptide from human plasma.

GHK · Glycyl-L-histidyl-L-lysine · Tripeptide-1 · NSC-379527

Compound

GHK-Cu

Prezatide copper is the Cu(II) coordination complex of the tripeptide glycyl-L-histidyl-L-lysine. The copper ion is part of the declared molecular identity and distinguishes this record from the free tripeptide.

Copper tripeptide-1 · GHK copper · Cu-GHK

binding-interaction

Cu(II) coordination

Formation of a discrete coordination complex between a peptide ligand and a Cu(II) ion. Spectroscopic study of the glycyl-L-histidyl-L-lysine complex reports a mononuclear 1:1 species at neutral pH with equatorial nitrogen coordination including the histidyl imidazole. Complex formation changes the molecular formula, mass, and analytical identity of the species relative to the free peptide, and is reversible by competing chelators.