parent and analog

GHK (Prezatide) vs Pal-GHK (Palmitoyl Tripeptide-1)

Pal-GHK is the N-palmitoylated derivative of the GHK tripeptide. Covalent acylation distinguishes it from free GHK.

Published: 2026-10-03Library record comparison: 2026-10-03

Identity side by side

Recorded molecular identities of GHK (Prezatide) and Pal-GHK (Palmitoyl Tripeptide-1)
Recorded field	GHK (Prezatide)	Pal-GHK (Palmitoyl Tripeptide-1)
Canonical name	Prezatide	Palmitoyl tripeptide-1
Aliases	GHK; Glycyl-L-histidyl-L-lysine; Tripeptide-1	Pal-GHK; N-palmitoyl-GHK; C16-GHK; Palmitoyl oligopeptide
Development codes	NSC-379527	not recorded
CAS	49557-75-7	147732-56-7
UNII	39TG2H631E	RV743D216M
PubChem CID	73587	10231864
Molecular formula	C14H24N6O4	C30H54N6O5
Molecular weight (Da)	340.38	578.8
Sequence length (residues)	3	3
Terminal modifications	not recorded	N-terminal palmitoylation
Structural modifications	not recorded	not recorded

GHK (Prezatide): nomenclature notes

GHK, GHK-Cu and Pal-GHK are three different substances: an uncomplexed peptide, a copper coordination species, and a covalently lipidated derivative. CAS 49557-75-7 belongs to THIS entry, the free tripeptide. The copper complex is 89030-95-5. That distinction has practical consequences — certificates of analysis in this market have carried the free-tripeptide number on copper-complex product, which describes the wrong substance.

Pal-GHK (Palmitoyl Tripeptide-1): nomenclature notes

'Palmitoyl oligopeptide' is not a unique identifier and should be kept only as a qualified alias; it is used for other lipidated peptides too. Pal-GHK is also not GHK-Cu with a delivery modification bolted on: acylating the N-terminal amine alters a group that participates in GHK's copper coordination, so copper behaviour must be measured for this molecule rather than inherited from the free ligand.

Recorded modification details

An aligned one-letter sequence is not recorded for this pair. The stored modification and sequence notes are shown below.

GHK (Prezatide)

Terminal modifications: not recorded
Structural modifications: not recorded
Stored three-letter notation: Gly · His · Lys · OH
Sequence notes: Three residues with a free N-terminal amine and a free C-terminal carboxyl. No modifications. Copper is NOT part of this entry — see nomenclatureNotes.

Pal-GHK (Palmitoyl Tripeptide-1)

Terminal modifications: N-terminal palmitoylation
Structural modifications: not recorded
Stored three-letter notation: Pal · Gly · His · Lys · OH
Sequence notes: The GHK tripeptide with a hexadecanoyl (palmitoyl) cap on the glycine alpha-amino group. 'Pal' is the acyl cap, not an amino-acid token. The lysine side-chain amine and the C-terminal carboxyl remain free. No copper is part of this identity.