Matrikine-derived peptides

Compound

KTTKS (Pentapeptide-4)

KTTKS is the unmodified pentapeptide from type I procollagen that forms the peptide backbone of the palmitoylated cosmetic ingredient Matrixyl.

Pentapeptide-4 · Collagen pentapeptide

Compound

Matrixyl

Palmitoyl pentapeptide-4 is the pentapeptide KTTKS with an N-terminal palmitoyl group, corresponding to a fragment sequence of type I procollagen.

Pal-KTTKS · Palmitoyl-KTTKS · Palmitoyl pentapeptide-3

Compound

Pal-GHK (Palmitoyl Tripeptide-1)

Pal-GHK is the N-palmitoylated derivative of the GHK tripeptide, used as a cosmetic ingredient and as an analytical internal standard.

Pal-GHK · N-palmitoyl-GHK · C16-GHK · Palmitoyl oligopeptide

Compound

GHK (Prezatide)

GHK is the uncomplexed tripeptide ligand of the GHK-copper complex, identified in 1977 as a growth-modulating tripeptide from human plasma.

GHK · Glycyl-L-histidyl-L-lysine · Tripeptide-1 · NSC-379527

Compound

GHK-Cu

Prezatide copper is the Cu(II) coordination complex of the tripeptide glycyl-L-histidyl-L-lysine. The copper ion is part of the declared molecular identity and distinguishes this record from the free tripeptide.

Copper tripeptide-1 · GHK copper · Cu-GHK

binding-interaction

Cu(II) coordination

Formation of a discrete coordination complex between a peptide ligand and a Cu(II) ion. Spectroscopic study of the glycyl-L-histidyl-L-lysine complex reports a mononuclear 1:1 species at neutral pH with equatorial nitrogen coordination including the histidyl imidazole. Complex formation changes the molecular formula, mass, and analytical identity of the species relative to the free peptide, and is reversible by competing chelators.