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Research Catalog

parent and analog

Humanin (HN) vs HNG ([Gly14]-Humanin)

HNG is the single-substitution humanin analog with glycine in place of serine at residue 14. The recorded sequences otherwise match.

Published: 2026-10-03Library record comparison: 2026-10-03

01

Identity side by side

Recorded molecular identities of Humanin (HN) and HNG ([Gly14]-Humanin)
Recorded fieldHumanin (HN)HNG ([Gly14]-Humanin)
Canonical nameHumanin[Gly14]-humanin
AliasesHNHNG; S14G-humanin; S14G-HN; Humanin-G
Development codesnot recordednot recorded
CAS330936-69-1330936-70-4
UNIIH975EUX36Gnot recorded
PubChem CID1613143816135997
Molecular formulaC119H204N34O32S2C118H202N34O31S2
Molecular weight (Da)2687.32657.2
Sequence length (residues)2424
Terminal modificationsFree N-terminus; Free C-terminal carboxylFree N-terminus; Free C-terminal carboxyl
Structural modificationsnot recordedS14G

Humanin (HN): nomenclature notes

The humanin coding sequence lies within MT-RNR2, the mitochondrial 16S rRNA gene. A mitochondrial coding locus does not establish where translation occurs. This record specifies the 24-residue standard-code form; a mitochondrial-code prediction is a distinct sequence. Nuclear humanin-like loci further complicate assigning endogenous origin. HNG carries S14G, and HNGF6A carries F6A and S14G. N-formyl humanin is a distinct chemical form. MTRNR2L gene names denote nuclear loci and are not peptide aliases.

HNG ([Gly14]-Humanin): nomenclature notes

HNG, S14G-HN and [Gly14]-humanin name the same substitution. 'Humanin-G' denotes substitution at position 14, not a glycine extension. HNGF6A additionally replaces Phe6 with alanine. These synthetic analogs require sequence-specific attribution; mitochondrial family membership does not establish endogenous expression.

02

Residue sequence comparison

Positions are numbered from each stored sequence’s first residue. Highlighted cells differ or extend beyond the other chain; a dash indicates no aligned residue. One-letter notation does not encode terminal groups or stereochemistry. Read the recorded notes below.

Aligned one-letter residue sequences
Humanin (HN)1M2A3P4R5G6F7S8C9L10L11L12L13T14S15E16I17D18L19P20V21K22R23R24A
HNG ([Gly14]-Humanin)1M2A3P4R5G6F7S8C9L10L11L12L13T14G15E16I17D18L19P20V21K22R23R24A

Differences in text

  • Humanin (HN): residue 14 = S; HNG ([Gly14]-Humanin): residue 14 = G.

Humanin (HN)

Terminal modifications
Free N-terminus; Free C-terminal carboxyl
Structural modifications
not recorded
Sequence notes
Twenty-four residues with free termini and one cysteine at position 8. This record specifies the standard-code form; it does not identify the mature product of mitochondrial translation.

HNG ([Gly14]-Humanin)

Terminal modifications
Free N-terminus; Free C-terminal carboxyl
Structural modifications
S14G
Sequence notes
Twenty-four residues, free at both termini. Identical to humanin except at position 14, where serine is replaced by glycine.

03

Recorded mechanisms

These lists show the links recorded in each monograph. An unlisted link does not establish its absence from the molecule’s biology.

Shared recorded links

not recorded

Recorded only for Humanin (HN)

not recorded

Recorded only for HNG ([Gly14]-Humanin)

not recorded

04

Recorded compound classes

Shared recorded links

Recorded only for Humanin (HN)

not recorded

Recorded only for HNG ([Gly14]-Humanin)

not recorded

05

References for the relationship

  1. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

    Hashimoto Y, Kurita M, Aiso S, Nishimoto I, Matsuoka M

    Molecular biology of the cell · 2009-04-22 · Journal Article

    current
    PMID 19386761PMC2695794DOI 10.1091/mbc.e09-02-0168Humanin (HN)HNG ([Gly14]-Humanin)

06

Read the full monographs

Humanin (HN) →HNG ([Gly14]-Humanin) →