Compound class

Mitochondrial-derived peptides

Peptides encoded by short open reading frames within the mitochondrial genome rather than the nuclear genome.

Published: 2026-09-04Literature/identifier verification: 2026-08-23

Neutral class definition

Peptides encoded by short open reading frames within the mitochondrial genome rather than the nuclear genome.

Related compounds

Compound

MOTS-c

MOTS-c is a sixteen-amino-acid peptide encoded by a short open reading frame within the mitochondrial 12S rRNA, rather than by the nuclear genome.

Mitochondrial open reading frame of the 12S rRNA-c

Related molecular mechanisms

signaling-pathway

A serine/threonine kinase complex that senses low cellular ATP and phosphorylates substrates that increase ATP generation and decrease ATP consumption. Reported as a central mediator of the cellular response to energetic stress and of multiple aspects of mitochondrial homeostasis.

Relevant glossary terms

Agonist Ligand G-protein-coupled receptor Peptide analog Lipidation Amidation

Verified bibliography

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P
Cell metabolism · 2015-03-03 · Journal Article
current
PMID 25738459 PMC4350682 DOI 10.1016/j.cmet.2015.02.009 MOTS-c AMP-activated protein kinase