Mitochondrial-derived peptides

Compound

HNGF6A

HNGF6A is a synthetic humanin analog with F6A and S14G substitutions, described as non-IGFBP-3-binding in a comparative disposition study.

HNGF6A · F6A/S14G-humanin

Compound

HNG ([Gly14]-Humanin)

HNG is a synthetic single-substitution analog of humanin carrying glycine in place of serine at position 14.

HNG · S14G-humanin · S14G-HN · Humanin-G

Compound

Humanin (HN)

Humanin is a 24-residue peptide encoded within the mitochondrial 16S ribosomal RNA gene, and the first-described member of the mitochondrial-derived peptide family.

HN

Compound

MOTS-c

MOTS-c is a sixteen-amino-acid peptide encoded by a short open reading frame within the mitochondrial 12S rRNA, rather than by the nuclear genome.

Mitochondrial open reading frame of the 12S rRNA-c

Compound

SHLP2

SHLP2 is a 26-residue peptide assigned to a small open reading frame within the mitochondrial 16S rRNA region. Its experimental characterization includes receptor screening, protein-interaction assays and targeted peptide detection.

SHLP-2

Compound

SHLP3

SHLP3 is a 38-residue peptide from the same mitochondrial region as humanin, characterised principally through the study that named the series.

SHLP-3

Compound

SHLP6

SHLP6 is a 20-residue peptide assigned to the mitochondrial 16S rRNA region and distinguished from other SHLP members by its sequence and reported cellular response.

SHLP-6

signaling-pathway

AMPK signaling

A serine/threonine kinase complex that senses low cellular ATP and phosphorylates substrates that increase ATP generation and decrease ATP consumption. Reported as a central mediator of the cellular response to energetic stress and of multiple aspects of mitochondrial homeostasis.