Molecular mechanism
G-actin sequestration
Binding of monomeric globular actin by a peptide ligand, holding it in a form unavailable for filament assembly. Beta-thymosins are reported as the main intracellular G-actin-sequestering peptides in most vertebrate cells, with a dissociation constant in the micromolar range that permits rapid binding and release.
See this target on the receptor map
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Neutral molecular overview
Binding of monomeric globular actin by a peptide ligand, holding it in a form unavailable for filament assembly. Beta-thymosins are reported as the main intracellular G-actin-sequestering peptides in most vertebrate cells, with a dissociation constant in the micromolar range that permits rapid binding and release.
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Target identifiers
- Gene symbols
- ACTB
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Related compounds
04
Related mechanisms
No related mechanism is declared in this seed record.
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Verified bibliography
Reference 1
currentReference 2
Actin dynamics.Pollard TD, Blanchoin L, Mullins RD
Journal of cell science · 2001-01 · Journal Article
currentReference 3
The beta-thymosin enigma.Sun HQ, Yin HL
Annals of the New York Academy of Sciences · 2007-05-10 · Review
currentReference 4
Thymosin beta4 and its posttranslational modifications.Hannappel E
Annals of the New York Academy of Sciences · 2010-04 · Review
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Hannappel E 2007 | Review article |
| Pollard TD et al. 2001 | No abstract available; study type not determined |
| Sun HQ et al. 2007 | Review article |
| Hannappel E 2010 | Review article |
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Related glossary terms
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Related Purely Peptides research articles
No existing Research Article is mapped to this mechanism seed record.