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Purely Peptides
Research Catalog

Molecular mechanism

G-actin sequestration

Binding of monomeric globular actin by a peptide ligand, holding it in a form unavailable for filament assembly. Beta-thymosins are reported as the main intracellular G-actin-sequestering peptides in most vertebrate cells, with a dissociation constant in the micromolar range that permits rapid binding and release.

Type: binding-interactionPublished: 2026-09-04Literature/identifier verification: 2026-08-23
Actin monomer bindingG-actin binding

01

Neutral molecular overview

Binding of monomeric globular actin by a peptide ligand, holding it in a form unavailable for filament assembly. Beta-thymosins are reported as the main intracellular G-actin-sequestering peptides in most vertebrate cells, with a dissociation constant in the micromolar range that permits rapid binding and release.

02

Target identifiers

Gene symbols
ACTB

03

Related compounds

Compound

Thymosin beta-4

Thymosin beta-4 is an N-terminally acetylated peptide originally isolated from a thymic tissue fraction and subsequently characterized as a G-actin-sequestering peptide.

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Related mechanisms

No related mechanism is declared in this seed record.

05

Verified bibliography

  1. beta-Thymosins.

    Hannappel E

    Annals of the New York Academy of Sciences · 2007-04-27 · Review

    current
    PMID 17468232DOI 10.1196/annals.1415.018Thymosin beta-4Actin monomer binding
  2. Actin dynamics.

    Pollard TD, Blanchoin L, Mullins RD

    Journal of cell science · 2001-01 · Journal Article

    current
    PMID 11112680DOI 10.1242/jcs.114.1.3Thymosin beta-4Actin monomer binding
  3. The beta-thymosin enigma.

    Sun HQ, Yin HL

    Annals of the New York Academy of Sciences · 2007-05-10 · Review

    current
    PMID 17495248DOI 10.1196/annals.1415.021Thymosin beta-4Actin monomer binding
  4. Thymosin beta4 and its posttranslational modifications.

    Hannappel E

    Annals of the New York Academy of Sciences · 2010-04 · Review

    current
    PMID 20536447DOI 10.1111/j.1749-6632.2010.05485.xThymosin beta-4Actin monomer binding

06

Related glossary terms

AgonistLigandG-protein-coupled receptor

07

Related Purely Peptides research articles

No existing Research Article is mapped to this mechanism seed record.