Molecular mechanism
GnRH receptor
The GnRH receptor is a G-protein-coupled receptor encoded in humans by GNRHR. The records linked here cite direct binding measurements for synthetic peptide analogs, made at the human receptor or, where stated, at the rat receptor expressed in cultured cells.
See this target on the receptor map
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Neutral molecular overview
The GnRH receptor is a G-protein-coupled receptor encoded in humans by GNRHR. The records linked here cite direct binding measurements for synthetic peptide analogs, made at the human receptor or, where stated, at the rat receptor expressed in cultured cells.
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Target identifiers
- Gene symbols
- GNRHR
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Related compounds
Compound
Leuprolide (leuprorelin)
Leuprorelin, also called leuprolide, is a synthetic nine-residue peptide with an L-pyroglutamyl residue at position 1, D-leucine at position 6 and an N-ethylamide on the C-terminal proline. This record describes the parent peptide without counterion or hydrate.
Compound
Triptorelin
Triptorelin is a synthetic ten-residue peptide with an L-pyroglutamyl residue at position 1, D-tryptophan at position 6 and a C-terminal glycinamide. This record describes the parent peptide without counterion.
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Related mechanisms
No related mechanism is declared in this seed record.
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Verified bibliography
Reference 1
Characterization of 12 GnRH peptide agonists - a kinetic perspective.Nederpelt I, Georgi V, Schiele F, Nowak-Reppel K, Fernández-Montalván AE, IJzerman AP, Heitman LH
British journal of pharmacology · 2015-11-04 · Journal Article
currentReference 2
Probing the GnRH receptor agonist binding site identifies methylated triptorelin as a new anti-proliferative agent.Morgan K, Leighton SP, Millar RP
Journal of molecular biochemistry · 2012-06-16 · Journal Article
currentReference 3
Impact of aromatic residues within transmembrane helix 6 of the human gonadotropin-releasing hormone receptor upon agonist and antagonist binding.Hövelmann S, Hoffmann SH, Kühne R, ter Laak T, Reiländer H, Beckers T
Biochemistry · 2002-01-29 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Nederpelt I et al. 2015 | Study models reported: in vitro · from the abstract |
| Morgan K et al. 2012 | Study models reported: in vitro · from the abstract |
| Hövelmann S et al. 2002 | Study models reported: in vitro · from the abstract |
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Related glossary terms
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Related Purely Peptides research articles
No existing Research Article is mapped to this mechanism seed record.