Molecular mechanism

Guanylate cyclase C receptor

Guanylate cyclase C is a receptor also designated GC-C. The cited studies characterize linaclotide in membrane-binding assays and evaluate peptide activity at this receptor.

Type: receptorPublished: 2026-10-22Literature/identifier verification: 2026-10-22

See this target on the receptor map

GC-CGC-2C

Neutral molecular overview

Guanylate cyclase C is a receptor also designated GC-C. The cited studies characterize linaclotide in membrane-binding assays and evaluate peptide activity at this receptor.

Target identifiers

No target identifier beyond the verified name and aliases is listed for this mechanism.

Related compounds

Compound

Linaclotide

Linaclotide is a synthetic 14-residue peptide with free termini and three intramolecular disulfide bridges.

Related mechanisms

No related mechanism is declared in this seed record.

Verified bibliography

Reference 1
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract.
Bryant AP, Busby RW, Bartolini WP, Cordero EA, Hannig G, Kessler MM, Pierce CM, Solinga RM, Tobin JV, Mahajan-Miklos S, Cohen MB, Kurtz CB, Currie MG
Life sciences · 2010-03-20 · Journal Article
current
PMID 20307554 DOI 10.1016/j.lfs.2010.03.015 Linaclotide GC-C
Reference 2
Improving the Gastrointestinal Stability of Linaclotide.
Braga Emidio N, Tran HNT, Andersson A, Dawson PE, Albericio F, Vetter I, Muttenthaler M
Journal of medicinal chemistry · 2021-05-12 · Journal Article
current
PMID 33979161 PMC8237258 DOI 10.1021/acs.jmedchem.1c00380 Linaclotide GC-C

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

Reference	Study models
Bryant AP et al. 2010	Study models reported: in vitro · from the abstract
Braga Emidio N et al. 2021	Study models reported: in vitro · from the abstract

Related glossary terms

Agonist Ligand G-protein-coupled receptor