Molecular mechanism
Innate repair receptor
A heteromeric receptor complex proposed in 2004 to comprise the erythropoietin receptor together with the beta common receptor (CD131), and described as distinct from the EPOR homodimer that mediates erythroid maturation. The proposal rests on co-purification and co-immunoprecipitation of the two receptors from tissue membranes, colocalization in protected cells, and the absence of erythropoietin's protective activity in beta common receptor knockout animals. It is disputed. An independent group examined the extracellular regions of the two receptors in silico and in vitro, in the presence and in the absence of erythropoietin or the erythropoietin-derived peptide cibinetide, reported that they do not specifically associate, and opens by calling the complex controversial. No biophysical demonstration of a direct association between the two receptors has been published. This record therefore describes a reported complex together with the test that failed to confirm it, not an established one. Peptides characterized as selective agonists at this complex are reported not to engage the homodimeric receptor.
See this target on the receptor map
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Neutral molecular overview
A heteromeric receptor complex proposed in 2004 to comprise the erythropoietin receptor together with the beta common receptor (CD131), and described as distinct from the EPOR homodimer that mediates erythroid maturation. The proposal rests on co-purification and co-immunoprecipitation of the two receptors from tissue membranes, colocalization in protected cells, and the absence of erythropoietin's protective activity in beta common receptor knockout animals. It is disputed. An independent group examined the extracellular regions of the two receptors in silico and in vitro, in the presence and in the absence of erythropoietin or the erythropoietin-derived peptide cibinetide, reported that they do not specifically associate, and opens by calling the complex controversial. No biophysical demonstration of a direct association between the two receptors has been published. This record therefore describes a reported complex together with the test that failed to confirm it, not an established one. Peptides characterized as selective agonists at this complex are reported not to engage the homodimeric receptor.
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Target identifiers
- Gene symbols
- EPOR, CSF2RB
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Related compounds
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Related mechanisms
No related mechanism is declared in this seed record.
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Verified bibliography
Reference 1
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.Nairz M, Haschka D, Dichtl S, Sonnweber T, Schroll A, Aßhoff M, Mindur JE, Moser PL, Wolf D, Swirski FK, Theurl I, Cerami A, Brines M, Weiss G
Scientific reports · 2017-10-12 · Journal Article
currentReference 2
Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor.Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, Latini R, Xie QW, Smart J, Su-Rick CJ, Pobre E, Diaz D, Gomez D, Hand C, Coleman T, Cerami A
Proceedings of the National Academy of Sciences of the United States of America · 2004-09-29 · Journal Article
currentReference 3
EPO does not promote interaction between the erythropoietin and beta-common receptors.Cheung Tung Shing KS, Broughton SE, Nero TL, Gillinder K, Ilsley MD, Ramshaw H, Lopez AF, Griffin MDW, Parker MW, Perkins AC, Dhagat U
Scientific reports · 2018-08-20 · Journal Article
currentreports againstReports against Innate repair receptor — Examined the extracellular regions of both receptors in silico and in vitro, in the presence and absence of erythropoietin or this peptide, and reports that they do not specifically associate.
Reference 4
Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin.Brines M, Patel NS, Villa P, Brines C, Mennini T, De Paola M, Erbayraktar Z, Erbayraktar S, Sepodes B, Thiemermann C, Ghezzi P, Yamin M, Hand CC, Xie QW, Coleman T, Cerami A
Proceedings of the National Academy of Sciences of the United States of America · 2008-08-01 · Journal Article
currentReference 5
ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain: an experimental study in rats and β-common receptor knockout mice.Swartjes M, Morariu A, Niesters M, Brines M, Cerami A, Aarts L, Dahan A
Anesthesiology · 2011-11 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Nairz M et al. 2017 | Study models reported: in vitro; animal (mouse) · from the abstract |
| Brines M et al. 2004 | Study models reported: in vitro; animal (mouse) · from the abstract |
| Cheung Tung Shing KS et al. 2018 | Study models reported: in vitro; animal (mouse) · from the abstractCorrection published: Sci Rep. 2019 May 21;9(1):7851. doi: 10.1038/s41598-019-43988-9. |
| Brines M et al. 2008 | Study models reported: in vitro; animal (rat, mouse, rabbit) · from the full text |
| Swartjes M et al. 2011 | Study models reported: animal (rat, mouse) · from the abstract |
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Related glossary terms
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Related Purely Peptides research articles
No existing Research Article is mapped to this mechanism seed record.