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Research Catalog

Molecular mechanism

Parathyroid hormone 1 receptor

PTH1R is a class B G-protein-coupled receptor encoded by PTH1R and also called the PTH/PTHrP receptor. The record linked here cites a direct binding measurement made at the human receptor expressed in a human kidney cell line.

Type: receptorPublished: 2026-10-15Literature/identifier verification: 2026-10-15

See this target on the receptor map

PTH1RPTH/PTHrP receptor

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Neutral molecular overview

PTH1R is a class B G-protein-coupled receptor encoded by PTH1R and also called the PTH/PTHrP receptor. The record linked here cites a direct binding measurement made at the human receptor expressed in a human kidney cell line.

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Target identifiers

Gene symbols
PTH1R

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Related compounds

Compound

Teriparatide

Teriparatide is the linear 34-residue peptide corresponding to residues 1-34 of human parathyroid hormone, with a free amino terminus and a free C-terminal carboxyl group. This record describes the peptide without counterion.

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Related mechanisms

No related mechanism is declared in this seed record.

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Verified bibliography

  1. Reference 1

    Comparison of recombinant human PTH(1-34) (LY333334) with a C-terminally substituted analog of human PTH-related protein(1-34) (RS-66271): In vitro activity and in vivo pharmacological effects in rats.

    Frolik CA, Cain RL, Sato M, Harvey AK, Chandrasekhar S, Black EC, Tashjian AH Jr, Hock JM

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999-02 · Journal Article

    current
    PMID 9933468DOI 10.1359/jbmr.1999.14.2.163TeriparatidePTH1R

  2. Reference 2

    Comparative Physicochemical and Biological Characterisation of the Similar Biological Medicinal Product Teriparatide and Its Reference Medicinal Product.

    Kovács P, Schäfer T, Háda V, Hevér H, Klingelhöfer S, Nebel M, Stadie T, Kiss R, Urbányi Z

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2020-02 · Comparative Study

    current
    PMID 31595483PMC6985066DOI 10.1007/s40259-019-00386-xTeriparatidePTH1R

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

ReferenceStudy models
Frolik CA et al. 1999Study models reported: in vitro; animal (rat) · from the abstract
Kovács P et al. 2020Study models reported: in vitro · from the abstract

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Related glossary terms

AgonistLigandG-protein-coupled receptor

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Related Purely Peptides research articles

No existing Research Article is mapped to this mechanism seed record.