Molecular mechanism

Thyrotropin-releasing hormone receptor

A class A G-protein-coupled receptor. Independent structural studies report the defined TRH tripeptide bound to human TRHR in receptor–G-protein complexes.

Type: receptorPublished: 2026-10-22Literature/identifier verification: 2026-10-22

See this target on the receptor map

Neutral molecular overview

A class A G-protein-coupled receptor. Independent structural studies report the defined TRH tripeptide bound to human TRHR in receptor–G-protein complexes.

Target identifiers

Gene symbols: TRHR

Related compounds

Compound

TRH (thyrotropin-releasing hormone)

Protirelin is a tripeptide comprising L-pyroglutamyl, L-histidyl and L-prolinamide units in that order.

Related mechanisms

No related mechanism is declared in this seed record.

Verified bibliography

Reference 1
Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor.
Xu Y, Cai H, You C, He X, Yuan Q, Jiang H, Cheng X, Jiang Y, Xu HE
Cell research · 2022-04-01 · Letter
current
PMID 35365755 PMC9437077 DOI 10.1038/s41422-022-00641-x TRH (thyrotropin-releasing hormone)Thyrotropin-releasing hormone receptor
Reference 2
Molecular basis for the activation of thyrotropin-releasing hormone receptor.
Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C
Cell discovery · 2022-10-25 · Letter
current
PMID 36280665 PMC9592576 DOI 10.1038/s41421-022-00477-0 TRH (thyrotropin-releasing hormone)Thyrotropin-releasing hormone receptor

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

Reference	Study models
Xu Y et al. 2022	Study models reported: in vitro · from the full text
Ji SY et al. 2022	Study models reported: in vitro · from the full text

Related glossary terms

Agonist Ligand G-protein-coupled receptor