HCG (Human Chorionic Gonadotropin) 5,000 IU
Human chorionic gonadotropin (HCG) is a glycoprotein hormone consisting of an alpha subunit (common to LH, FSH, TSH) and a unique beta subunit that confers biological specificity. HCG mimics luteinizing hormone (LH) activity by binding the LH/CG receptor on Leydig cells and ovarian theca cells. It is a non-covalent heterodimer of a 92-residue alpha subunit (UniProt P01215, shared with LH, FSH and TSH) and a 145-residue beta subunit (UniProt P0DN86) that confers its identity; no single molecular formula can be assigned, because eight glycosylation sites carry carbohydrate that varies between preparations (~30% of mass; unglycosylated backbone ~25,700 Da). It has a significantly longer half-life than LH due to its greater degree of glycosylation, making it a durable LH-receptor agonist for research applications requiring sustained Leydig cell or theca cell stimulation. This 5,000 IU presentation suits shorter protocols and dose-ranging work where a 10,000 IU vial would exceed the reconstituted working window. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
Strength
Select Option
2+ save 5% · 5+ save 10% · 10+ save 20%
- Free Priority shipping on US orders over $100
- Ships same day on orders before 2 PM MST
- Discreet, unmarked packaging
- Third-party tested to a 99%+ purity standard
Mechanism of Action
HCG binds the LH/CG receptor (LHCGR), a Gs-coupled GPCR on testicular Leydig cells, activating cAMP/PKA signaling that stimulates steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme (CYP11A1), thereby driving de novo testosterone biosynthesis. In ovarian tissue, HCG triggers final oocyte maturation, ovulation, and corpus luteum formation. HCG also maintains intratesticular testosterone concentrations necessary for spermatogenesis, independently of pituitary LH.
Properties
CAS Number
9002-61-3
Molecular Weight
~36,700 Da
Half-Life
~24-36 hours
Storage
Store lyophilized at 2-8°C. Reconstituted at 2-8°C, use within 30 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- Held to a 99%+ purity specification.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published per production lot as testing completes — see the 6 published so far.
Research Applications
References & Citations
(2)Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression
Coviello AD, Matsumoto AM, Bremner WJ, et al.
Biological functions of hCG and hCG-related molecules
Cole LA.
Related Products
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.