Selank
10mg
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) combining the tuftsin tetrapeptide (Thr-Lys-Pro-Arg) with the Pro-Gly-Pro (PGP) stabilizing sequence also used in Semax. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank is classified as an anxiolytic and nootropic peptide in Russian pharmacopoeia. It modulates GABAergic neurotransmission and has demonstrated anxiolytic effects comparable to benzodiazepines without sedation, motor impairment, or dependence potential in preclinical models.
Pricing
Mechanism of Action
Selank enhances GABA-A receptor sensitivity to GABA without direct benzodiazepine site binding, increasing GABAergic inhibitory tone in limbic structures. It also modulates serotonin metabolism by inhibiting enkephalinase activity, increasing endogenous enkephalin levels. Additionally, Selank upregulates IL-6 expression, modulates T-helper cell balance (Th1/Th2), and enhances NK cell activity, indicating immunomodulatory properties. The tuftsin component is a known phagocytosis-stimulating peptide recognized by neutrophils and macrophages.
Properties
Molecular Formula
C₃₃H₅₇N₁₁O₉
Molecular Weight
751.87 Da
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Half-Life
~3-5 minutes (peripheral)
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(2)Anxiolytic action of the synthetic peptide Selank
Seredenin SB, Kozlovskii II, Blednov YA, et al.
Personality, coping style and humoral immunity
Zozulya AA, Gabaeva MV, Sokolov OYu, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.