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Catalog/Semaglutide
Semaglutide
#1048
Lyophilized Peptide

Semaglutide 30mg

Semaglutide is an acylated analog of human GLP-1 with Aib8 and Arg34 substitutions and derivatization at Lys26. Its receptor affinity and albumin binding were characterized in the discovery study by Lau et al. (2015). The reported mini-pig plasma pharmacokinetics do not establish an in-vitro half-life. This listing contains 30mg of lyophilized material. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.

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  • Reported measurements · lot SEM-20260828-01Bioviridian Inc. · COA8900: purity 99.78%; content 31.38 mg.Krause Analytical LLC · sample muz22ts · Lab #214175: purity 98.8%; content 32.3 mg.Krause Analytical LLC · sample tes8zb2 · Lab #214174: purity 98.6%; content 33.4 mg.Lot attribution — Purely Peptides owner: These two vials were submitted to Finnrick under lot code GHK-20260828-01, our GHK-Cu lot from the same fill date, in error. The laboratory confirmed the material as semaglutide against a 30 mg label claim. They are listed under SEM-20260828-01, the 30 mg semaglutide lot from that fill, as our best attribution; the laboratory did not confirm the lot.
  • Stock-solution arithmetic — Semaglutide concentration calculator

Batch Tracking

Batch #

SEM-20260828-01

Tested

2026-09-08

Purity

Bioviridian Inc. · COA8900: purity 99.78%; content 31.38 mg.Krause Analytical LLC · sample muz22ts · Lab #214175: purity 98.8%; content 32.3 mg.Krause Analytical LLC · sample tes8zb2 · Lab #214174: purity 98.6%; content 33.4 mg.Lot attribution — Purely Peptides owner: These two vials were submitted to Finnrick under lot code GHK-20260828-01, our GHK-Cu lot from the same fill date, in error. The laboratory confirmed the material as semaglutide against a 30 mg label claim. They are listed under SEM-20260828-01, the 30 mg semaglutide lot from that fill, as our best attribution; the laboratory did not confirm the lot.

Method

RP-HPLC (214 nm)

View Certificate of Analysis
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Mechanism of Action

Semaglutide is a GLP-1 receptor agonist. Lau et al. (2015) characterized receptor affinity and albumin binding while optimizing acylated GLP-1 analogs. Semaglutide contains Aib8 and Arg34 substitutions and a Lys26-linked substituent; the study reported increased albumin affinity relative to liraglutide.

Properties

CAS Number

910463-68-2

Molecular Formula

C₁₈₇H₂₉₁N₄₅O₅₉

Molecular Weight

4113.64 Da

Sequence

His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18 diacid-γGlu-OEG-OEG)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly

Half-Life

In-vitro half-life not established by the cited discovery study

Storage

Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 30 days.

Shipping & Delivery

  • Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
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Quality & Testing

  • Independently tested by Bioviridian Inc. — identity by LC-MS/MS, purity by RP-HPLC (214 nm).
  • Reported measurements on lot SEM-20260828-01:Bioviridian Inc. · COA8900: purity 99.78%; content 31.38 mg.Krause Analytical LLC · sample muz22ts · Lab #214175: purity 98.8%; content 32.3 mg.Krause Analytical LLC · sample tes8zb2 · Lab #214174: purity 98.6%; content 33.4 mg.Lot attribution — Purely Peptides owner: These two vials were submitted to Finnrick under lot code GHK-20260828-01, our GHK-Cu lot from the same fill date, in error. The laboratory confirmed the material as semaglutide against a 30 mg label claim. They are listed under SEM-20260828-01, the 30 mg semaglutide lot from that fill, as our best attribution; the laboratory did not confirm the lot.
  • USA-based; dispatched from Phoenix, Arizona.
  • Supplied strictly for in-vitro laboratory research — not for human use.

Additional laboratory results (2)

Krause Analytical LLC · sample muz22ts · Lab #214175

Tested by Krause Analytical LLC; commissioned through Finnrick.

The certificate’s Batch/Lot field shows the Finnrick sample code muz22ts. We list this result under lot SEM-20260828-01.

Chromatographic purity
98.8%
Method: HPLC-UV/MS
Measured content
32.3 mg
Method: HPLC-UV-MS
Identity (mass spectral match)
ID Confirmed
Method: HPLC-UV-MS
Label claim
30 mg
% of label, as printed
107.8
COC#
145871
Received
2026-09-18
Analyzed
2026-09-25
Report issued
2026-10-01
Laboratory address
8127 Mesa Drive Suite B-206, Austin, TX 78759
Laboratory director
Mark C. Krause
PDF SHA-256
5eb1ffa5d911590d5bc29e05ed565ae05c9aa686243d94cd1e26985ce38efb21
Original full certificate (PDF) · muz22ts

Krause Analytical LLC · sample tes8zb2 · Lab #214174

Tested by Krause Analytical LLC; commissioned through Finnrick.

The certificate’s Batch/Lot field shows the Finnrick sample code tes8zb2. We list this result under lot SEM-20260828-01.

Chromatographic purity
98.6%
Method: HPLC-UV/MS
Measured content
33.4 mg
Method: HPLC-UV-MS
Identity (mass spectral match)
ID Confirmed
Method: HPLC-UV-MS
Label claim
30 mg
% of label, as printed
111.5
COC#
145871
Received
2026-09-18
Analyzed
2026-09-25
Report issued
2026-10-01
Laboratory address
8127 Mesa Drive Suite B-206, Austin, TX 78759
Laboratory director
Mark C. Krause
PDF SHA-256
ef454a2fb5468879a483654c6467965589e6edcf60eeca408874d536ec400d6d
Original full certificate (PDF) · tes8zb2
Lot SEM-20260828-01 · certificatesBioviridian Inc. · COA8900: purity 99.78%; content 31.38 mg.Krause Analytical LLC · sample muz22ts · Lab #214175: purity 98.8%; content 32.3 mg.Krause Analytical LLC · sample tes8zb2 · Lab #214174: purity 98.6%; content 33.4 mg.Lot attribution — Purely Peptides owner: These two vials were submitted to Finnrick under lot code GHK-20260828-01, our GHK-Cu lot from the same fill date, in error. The laboratory confirmed the material as semaglutide against a 30 mg label claim. They are listed under SEM-20260828-01, the 30 mg semaglutide lot from that fill, as our best attribution; the laboratory did not confirm the lot.

Research Applications

1GLP-1 receptor affinity characterization
2Albumin-binding comparisons
3Acylated GLP-1 analog structure-activity research

References & Citations

(1)
1

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

Lau J, Bloch P, Schäffer L, et al.

J Med Chem (2015)PMID: 26308095 DOI

Research Use Only

This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.

Research reference

A published identity, mechanism, and bibliography record corresponds to this catalog entry.

Research reference: Semaglutide

More references from the Research Library (6)

Further papers cited in the Library's Semaglutide record, each checked against PubMed. They describe the compound in research settings and are not statements about this product. See the full record for its identity, structure and complete bibliography.

  1. Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes.

    Zhang X, Belousoff MJ, Liang YL, et al.

    Cell reports (2021)In vitroPMID 34260945
  2. The Discovery and Development of Liraglutide and Semaglutide.

    Knudsen LB, Lau J

    Frontiers in endocrinology (2019)Review articlePMID 31031702
  3. Semaglutide lowers body weight in rodents via distributed neural pathways.

    Gabery S, Salinas CG, Paulsen SJ, et al.

    JCI insight (2020)In vitro · AnimalPMID 32213703
  4. Pharmacology, physiology, and mechanisms of incretin hormone action.

    Campbell JE, Drucker DJ

    Cell metabolism (2013)Review articlePMID 23684623
  5. Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.

    Zhang Y, Sun B, Feng D, et al.

    Nature (2017)In vitroPMID 28538729
  6. Structural basis for ligand recognition of incretin receptors.

    Underwood CR, Parthier C, Reedtz-Runge S

    Vitamins and hormones (2010)Review articlePMID 21094903