GLP-1 receptor peptide analogs

Compound

Exenatide

Exenatide is a 39-residue peptide with an N-terminal histidine and a C-terminal serine amide, originally isolated from Heloderma suspectum venom and characterized as a member of the glucagon superfamily.

Exendin-4

Compound

Liraglutide

Liraglutide is an acylated peptide analog of glucagon-like peptide-1, characterized against the GLP-1 receptor.

NN2211

Compound

Semaglutide

Semaglutide is an acylated peptide analog of glucagon-like peptide-1. Its discovery record identifies two amino-acid substitutions and derivatization at Lys26.

NN9535 · NNC 0113-0217

receptor

Glucagon-like peptide-1 receptor

GLP-1R is a class B G-protein-coupled receptor. The cited structural and pharmacology records characterize semaglutide and retatrutide as peptide agonists at this receptor.