Compound class
Nonpeptide receptor agonists
Small molecules characterized as agonists at receptors whose endogenous ligands are peptides, included here for comparison with the peptide agonists at the same receptor.
01
Neutral class definition
Small molecules characterized as agonists at receptors whose endogenous ligands are peptides, included here for comparison with the peptide agonists at the same receptor.
02
Related compounds
03
Related molecular mechanisms
04
Relevant glossary terms
05
Verified bibliography
Reference 1
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.Sloop KW, Cox AL, Wainscott DB, White A, Droz BA, Stutsman C, Showalter AD, Suter TM, Dunbar JD, Snider BM, O'Farrell LS, Hewitt N, Ruble JC, Padgett LR, Woerly EM, Peterson JA, Coskun T, Liu Z, Coutant DE, Ai M, Emmerson PJ, Sangwung P, Willard FS
Science translational medicine · 2024-12-18 · Journal Article
currentReference 2
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW
Proceedings of the National Academy of Sciences of the United States of America · 2020-11-11 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Sloop KW et al. 2024 | Study models reported: in vitro; animal (mouse, rat) · from the abstract |
| Kawai T et al. 2020 | Study models reported: in vitro; animal (mouse, rat, cynomolgus monkey) · from the full text |
06
Related Purely Peptides research articles
No existing Research Article is mapped to this class seed record.
07