Compound class
Growth hormone secretagogues
Endogenous peptide ligands, synthetic peptides and nonpeptide mimetics acting at the growth hormone secretagogue receptor (the ghrelin receptor), a distinct receptor from the GHRH receptor targeted by GHRH analogs.
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Neutral class definition
Endogenous peptide ligands, synthetic peptides and nonpeptide mimetics acting at the growth hormone secretagogue receptor (the ghrelin receptor), a distinct receptor from the GHRH receptor targeted by GHRH analogs.
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Related compounds
Compound
Anamorelin
Anamorelin is a nonpeptide small-molecule agonist at the ghrelin receptor, structurally unrelated to the peptide secretagogues that share its target.
ONO-7643 · RC-1291 · ST-1291
Compound
Examorelin (Hexarelin)
Examorelin, widely supplied as hexarelin, is a synthetic hexapeptide growth hormone secretagogue carrying a 2-methylated D-tryptophan.
Hexarelin · EP-23905 · MF-6003
Compound
Human Octanoyl-Ghrelin
Human octanoyl-ghrelin is the endogenous 28-residue acylated peptide ligand of the ghrelin receptor, carrying an n-octanoyl ester on serine 3.
Lenomorelin · Human acyl-ghrelin · Acyl-ghrelin
Compound
GHRP-6
GHRP-6 is a synthetic hexapeptide with a C-terminal amide, characterized as an agonist at the growth hormone secretagogue receptor.
Hexapeptide-2 · Growth hormone-releasing peptide-6
Compound
Ipamorelin
Ipamorelin is a synthetic pentapeptide with a C-terminal amide, characterized in its original report as a growth hormone secretagogue acting through a GHRP-like receptor rather than the GHRH receptor.
NNC 26-0161
Compound
Macimorelin
Macimorelin is a gem-diamino peptidomimetic agonist at the ghrelin receptor.
AEZS-130 · JMV 1843 · EP-1572
Compound
Pralmorelin (GHRP-2)
Pralmorelin is a synthetic hexapeptide growth hormone secretagogue acting at the ghrelin receptor, containing three D-configured residues and a naphthylalanine substitution.
GHRP-2 · Growth hormone-releasing peptide-2 · KP-102
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Related molecular mechanisms
receptor
Growth hormone secretagogue receptor
A G-protein-coupled receptor distinct from the GHRH receptor. Antagonist profiling reported that ipamorelin releases growth hormone through a GHRP-like receptor rather than through the GHRH receptor, establishing the two pathways as separate.
receptor
CD36 scavenger receptor
A multifunctional scavenger receptor, distinct from the growth hormone secretagogue receptor, reported as a binding target for certain synthetic secretagogue peptides. It is recorded separately here precisely because collapsing it into the ghrelin-receptor mechanism would erase the finding that these compounds are not pharmacologically interchangeable.
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Relevant glossary terms
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Verified bibliography
Reference 1
Ipamorelin, the first selective growth hormone secretagogue.Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH
European journal of endocrinology · 1998-11 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Raun K et al. 1998 | Study models reported: in vitro; animal (rat, swine) · from the abstract |
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Related Purely Peptides research articles
No existing Research Article is mapped to this class seed record.
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