Growth hormone secretagogues

Compound

Anamorelin

Anamorelin is a nonpeptide small-molecule agonist at the ghrelin receptor, structurally unrelated to the peptide secretagogues that share its target.

ONO-7643 · RC-1291 · ST-1291

Compound

Examorelin (Hexarelin)

Examorelin, widely supplied as hexarelin, is a synthetic hexapeptide growth hormone secretagogue carrying a 2-methylated D-tryptophan.

Hexarelin · EP-23905 · MF-6003

Compound

Human Octanoyl-Ghrelin

Human octanoyl-ghrelin is the endogenous 28-residue acylated peptide ligand of the ghrelin receptor, carrying an n-octanoyl ester on serine 3.

Lenomorelin · Human acyl-ghrelin · Acyl-ghrelin

Compound

GHRP-6

GHRP-6 is a synthetic hexapeptide with a C-terminal amide, characterized as an agonist at the growth hormone secretagogue receptor.

Hexapeptide-2 · Growth hormone-releasing peptide-6

Compound

Ipamorelin

Ipamorelin is a synthetic pentapeptide with a C-terminal amide, characterized in its original report as a growth hormone secretagogue acting through a GHRP-like receptor rather than the GHRH receptor.

NNC 26-0161

Compound

Macimorelin

Macimorelin is an orally active gem-diamino peptidomimetic agonist at the ghrelin receptor.

AEZS-130 · JMV 1843 · EP-1572

Compound

Pralmorelin (GHRP-2)

Pralmorelin is a synthetic hexapeptide growth hormone secretagogue acting at the ghrelin receptor, containing three D-configured residues and a naphthylalanine substitution.

GHRP-2 · Growth hormone-releasing peptide-2 · KP-102

receptor

Growth hormone secretagogue receptor

A G-protein-coupled receptor distinct from the GHRH receptor. Antagonist profiling reported that ipamorelin releases growth hormone through a GHRP-like receptor rather than through the GHRH receptor, establishing the two pathways as separate.

receptor

CD36 scavenger receptor

A multifunctional scavenger receptor, distinct from the growth hormone secretagogue receptor, reported as a binding target for certain synthetic secretagogue peptides. It is recorded separately here precisely because collapsing it into the ghrelin-receptor mechanism would erase the finding that these compounds are not pharmacologically interchangeable.