Compound class

Linear melanocortin analogs

Full-length melanocortin peptide analogs that retain a linear backbone, distinguished from the cyclic lactam analogs and from the short melanocortin fragments.

Published: 2026-09-13Literature/identifier verification: 2026-09-13

Neutral class definition

Full-length melanocortin peptide analogs that retain a linear backbone, distinguished from the cyclic lactam analogs and from the short melanocortin fragments.

Related compounds

Compound

Melanotan I (Afamelanotide)

Afamelanotide, widely supplied as Melanotan I, is a linear thirteen-residue analog of alpha-melanocyte-stimulating hormone carrying norleucine and D-phenylalanine substitutions.

Melanotan I · Melanotan-1 · MT-I · MT-1 · NDP-MSH · NDP-alpha-MSH · CUV1647 · MBJ05

Related molecular mechanisms

receptor

A family of five G protein-coupled receptors, MC1R through MC5R. ACTH recognition and signaling at MC2R depend on the accessory protein MRAP. Native hormones, peptide analogs and nonpeptide ligands differ in receptor-subtype recognition and functional direction; binding affinity, agonism and antagonism must be interpreted separately in the experimental system studied.