Compound class
Melanocortin receptor ligands
An umbrella for everything that acts at the melanocortin receptors regardless of chemistry — the native hormones, their fragments, cyclic analogs and nonpeptide small molecules. It exists so the native hormone is not filed as an analog of itself and a nonpeptide is not filed in a peptide class.
01
Neutral class definition
An umbrella for everything that acts at the melanocortin receptors regardless of chemistry — the native hormones, their fragments, cyclic analogs and nonpeptide small molecules. It exists so the native hormone is not filed as an analog of itself and a nonpeptide is not filed in a peptide class.
02
Related compounds
Compound
alpha-MSH
alpha-MSH is the endogenous thirteen-residue melanocortin peptide hormone from which several of the synthetic compounds in this library are derived.
α-MSH · alpha-MSH · alpha-melanotropin · Melanotropin alpha
Compound
Cosyntropin (ACTH 1-24)
Cosyntropin is the synthetic 1-24 fragment of adrenocorticotropic hormone, the melanocortin ligand of the MC2R branch.
Tetracosactide · ACTH(1-24) · alpha 1-24 corticotropin
Compound
Setmelanotide
Setmelanotide is a synthetic disulfide-cyclized octapeptide characterised as an MC4R-preferring melanocortin receptor agonist. A review by Swan et al. (PMID 38834138) describes setmelanotide as an analogue of alpha-melanocyte-stimulating hormone; that is a review-level parent attribution, not a residue-by-residue design account.
RM-493 · BIM-22493 · IRC-022493
Compound
SHU9119
SHU9119 is a cyclic lactam melanocortin analog whose receptor behaviour is subtype-dependent: antagonist at some melanocortin receptors and agonist at others. Gimenez et al. (PMID 35404053) describe SHU9119 as a cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone.
SHU-9119 · SHU 9119
Compound
THIQ
THIQ is a nonpeptide small-molecule agonist at the melanocortin-4 receptor, included here as the nonpeptide comparator to the melanocortin peptides.
03
Related molecular mechanisms
04
Relevant glossary terms
05
Verified bibliography
Reference 1
Structural insights into ligand recognition and activation of the melanocortin-4 receptor.Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y
Cell research · 2021-08-25 · Journal Article
currentReference 2
Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD
Journal of medicinal chemistry · 1995-09-01 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Zhang H et al. 2021 | Study models reported: in vitro · from the abstract |
| Hruby VJ et al. 1995 | Study models reported: in vitro · from the abstract |
06
Related Purely Peptides research articles
No existing Research Article is mapped to this class seed record.
07