Compound class
Regulatory peptide fragment analogs
Short synthetic peptides constructed from a fragment of a larger endogenous regulatory peptide, commonly extended with a stabilizing C-terminal sequence.
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Neutral class definition
Short synthetic peptides constructed from a fragment of a larger endogenous regulatory peptide, commonly extended with a stabilizing C-terminal sequence.
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Related compounds
Compound
AOD-9604
AOD-9604 is a synthetic, sixteen-residue human GH1 fragment analog specified with an N-terminal tyrosine, free termini and one intramolecular disulfide. AOD-9604 is used here as a provisional development-code name; an INN or USAN has not been established for this record.
Tyr-hGH(177-191) · AOD9604
Compound
N-Acetyl Selank Amidate
N-Acetyl Selank Amidate is the Selank heptapeptide with an acetyl group on the N-terminal threonine residue and an amide at the C-terminal proline. These covalent terminal changes define a distinct molecule.
Compound
N-Acetyl Semax Amidate
N-Acetyl Semax Amidate is the Semax heptapeptide with an acetyl group on the N-terminal methionine residue and an amide at the C-terminal proline. These covalent terminal changes define a distinct molecule.
Compound
PE 22-28
PE 22-28 is a synthetic heptapeptide corresponding to residues 22 to 28 of the sortilin propeptide. It is not a fragment of spexin; see the nomenclature note.
PE(22-28) · Sortilin propeptide (22-28)
Compound
Selank
Selank is a synthetic heptapeptide consisting of the tetrapeptide tuftsin extended at the C-terminus with the tripeptide Pro-Gly-Pro.
Selanc · Tuftsin-Pro-Gly-Pro · TP-7 · TP-7
Compound
Semax
Semax is a synthetic heptapeptide corresponding to residues 4 to 7 of adrenocorticotropic hormone extended at the C-terminus with the tripeptide Pro-Gly-Pro.
ACTH(4-7)-Pro-Gly-Pro
Compound
TB-500
Analytical studies have identified an N-terminally acetylated heptapeptide with the residue sequence LKKTETQ in material labeled TB-500. The designation alone does not establish the complete molecular identity of another preparation.
N-acetyl-thymosin beta-4 (17-23)
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Related molecular mechanisms
No published mechanisms are currently linked to this category.
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Relevant glossary terms
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Verified bibliography
Reference 1
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.Mazella J, Pétrault O, Lucas G, Deval E, Béraud-Dufour S, Gandin C, El-Yacoubi M, Widmann C, Guyon A, Chevet E, Taouji S, Conductier G, Corinus A, Coppola T, Gobbi G, Nahon JL, Heurteaux C, Borsotto M
PLoS biology · 2010-04-13 · Journal Article
currentReference 2
Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity.Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M
Frontiers in pharmacology · 2017-09-12 · Journal Article
currentReference 3
Detection and in vitro metabolism of AOD9604.Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D
Drug testing and analysis · 2014-09-10 · Journal Article
currentReference 4
Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential.Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P
Drug testing and analysis · 2012-09-07 · Journal Article
currentReference 5
Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry.Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD
Journal of chromatography. A · 2012-09-23 · Journal Article
currentReference 6
TB500/TB1000 and SGF1000: A scientific approach for a better understanding of misbranded and adulterated drugs.Delcourt V, Garcia P, Chabot B, Barnabé A, Bouscarel M, Loup B, Popot MA, Bailly-Chouriberry L
Drug testing and analysis · 2022-12-23 · Journal Article
currentReference 7
The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.Vanhee C, Francotte A, Janvier S, Deconinck E
Drug testing and analysis · 2020-01-29 · Journal Article
currentReference 8
One-Pot Peptide Ligation-Oxidative Cyclization Protocol for the Preparation of Short-/Medium-Size Disulfide Cyclopeptides.Spengler J, Blanco-Canosa JB, Forni L, Albericio F
Organic letters · 2018-06-28 · Journal Article
currentReference 9
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J
Brain research · 2006-09-22 · Journal Article
currentReference 10
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P
Frontiers in pharmacology · 2016-02-18 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Mazella J et al. 2010 | Study models reported: in vitro; animal (mouse) · from the abstract |
| Djillani A et al. 2017 | Study models reported: in vitro; animal (mouse) · from the abstract |
| Cox HD et al. 2014 | Study models reported: in vitro · from the abstract |
| Esposito S et al. 2012 | Chemical, structural or analytical study; no biological model reported |
| Ho EN et al. 2012 | Study models reported: in vitro; animal (horse) · from the abstract |
| Delcourt V et al. 2022 | Chemical, structural or analytical study; no biological model reported |
| Vanhee C et al. 2020 | Chemical, structural or analytical study; no biological model reported |
| Spengler J et al. 2018 | Chemical, structural or analytical study; no biological model reported |
| Dolotov OV et al. 2006 | Study models reported: animal (rat) · from the abstract |
| Volkova A et al. 2016 | Study models reported: animal (rat) · from the abstract |
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Related Purely Peptides research articles
No existing Research Article is mapped to this class seed record.
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