Thymosin-related peptides

Compound

Ac-SDKP (Goralatide)

Ac-SDKP is the acetylated N-terminal tetrapeptide of thymosin beta-4, generated from the parent by sequential enzymatic processing.

Ac-SDKP · Seraspenide · N-acetyl-seryl-aspartyl-lysyl-proline

Compound

Thymosin beta-4

Thymosin beta-4 is an N-terminally acetylated peptide originally isolated from a thymic tissue fraction and subsequently characterized as a G-actin-sequestering peptide.

Thymosin b4 · Tbeta4 · TB4

binding-interaction

G-actin sequestration

Binding of monomeric globular actin by a peptide ligand, holding it in a form unavailable for filament assembly. Beta-thymosins are reported as the main intracellular G-actin-sequestering peptides in most vertebrate cells, with a dissociation constant in the micromolar range that permits rapid binding and release.